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Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication used to treat skin diseases like harlequin-type ichthyosis, and lamellar ichthyosis, and severe cystic acne or moderate acne that is unresponsive to antibiotics. [6]
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Low-dose or microdosed Accutane is an off-label use of isotretinoin, or Accutane, by which patients take a lower dose of the medication over a longer period of time. But does it make enough of a ...
Isotretinoin is a pharmaceutical derivative of retinoic acid (a metabolite of vitamin A). Its mechanism of action is believed to involve reduction in the amount of sebum produced by sebaceous glands on the skin's surface.
The name isotretinoin is the same root tretinoin plus the prefix iso-. Regarding pronunciation, the following variants apply equally to both tretinoin and isotretinoin. Given that retinoic is pronounced / ˌ r ɛ t ɪ ˈ n oʊ ɪ k /, [43] [44] [42] [45] it is natural that / ˌ t r ɛ t ɪ ˈ n oʊ ɪ n / is a commonly heard pronunciation.
Retinoic acid (simplified nomenclature for all-trans-retinoic acid) is a metabolite of vitamin A 1 (all-trans-retinol) that is required for embryonic development, male fertility, regulation of bone growth and immune function. [2]
Other treatments with tentative benefit include brimonidine cream, ivermectin cream, and isotretinoin. [4] Dermabrasion or laser surgery may also be used. [3] The use of sunscreen is typically recommended. [3] Rosacea affects between 1% and 10% of people. [2] Those affected are most often 30 to 50 years old and female. [2]
Prescriptions to treat acne are often antibiotics. However, with the rise of antibiotic resistance, antibiotics are now often combined with broad-spectrum antibacterial agents such as benzoyl peroxide, and other medications like isotretinoin (commonly known by the brand name Accutane) are being used on patients with severe or resistant acne. [23]
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