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Queen Victoria's sons Edward VII, Alfred, Duke of Saxe-Coburg and Gotha, and Prince Arthur, Duke of Connaught and Strathearn were not haemophiliacs; however, her daughters Alice and Beatrice were confirmed carriers of the gene, and Victoria's son Leopold had haemophilia, making his daughter Princess Alice, Countess of Athlone a carrier as well.
In practice, Wilson's first reason would have required the Duchess's lover to be haemophiliac – an extremely unlikely survival, given the poor state of medicine at the time, [36] or the Duchess herself to be a carrier of haemophilia, since haemophilia is X-linked, meaning that her mother would have been a carrier, if haemophilia was not ...
Haemophilia has featured prominently in European royalty and thus is sometimes known as 'the royal disease'. Queen Victoria passed the mutation for haemophilia B [72] [73] to her son Leopold and, through two of her daughters, Alice and Beatrice, to various royals across the continent, including the royal families of Spain, Germany, and Russia.
Queen Victoria, and her daughters Princesses Alice and Beatrix, were carriers of the hemophilia gene (an abnormal allele of a gene, necessary to produce one of the blood clotting factors). Both had children who continued to pass on the gene to succeeding generations of the royal houses of Spain and Russia , into which they married. [ 3 ]
Victoria's youngest son, Leopold, was affected by the blood-clotting disease haemophilia B and at least two of her five daughters, Alice and Beatrice, were carriers. Royal haemophiliacs descended from Victoria included her great-grandsons, Alexei Nikolaevich, Tsarevich of Russia ; Alfonso, Prince of Asturias ; and Infante Gonzalo of Spain . [ 229 ]
Princess Alice, Countess of Athlone (Alice Mary Victoria Augusta Pauline; 25 February 1883 – 3 January 1981) was a member of the British royal family.She was the longest-lived Princess of the Blood Royal, and one of the longest-lived British royals.
A granddaughter of Queen Victoria, Alexandra was one of the most famous royal carriers of hemophilia and passed the condition to her son, Alexei Nikolaevich, Tsarevich of Russia. Alexandra was deeply involved in the personal and political life of her husband, Tsar Nicholas II.
Both George III and the Duke of Kent died in January 1820. The Prince Regent became George IV and Victoria was third in line to the throne after her uncles, the Duke of York and Duke of Clarence (the future William IV). She would ultimately take the throne as Queen Victoria in 1837. A pedigree showing the succession of Victoria to the throne