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  2. IGHE - Wikipedia

    en.wikipedia.org/wiki/IGHE

    n/a Ensembl ENSG00000211891 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.6 – 105.6 Mb n/a PubMed search n/a Wikidata View/Edit Human Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene. Function IGHE (Immunoglobulin Heavy constant Epsilon), (located on chromosome 14 for humans) has been predicted to enable ...

  3. Immunoglobulin E - Wikipedia

    en.wikipedia.org/wiki/Immunoglobulin_E

    Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isoform") that has been found only in mammals. IgE is synthesised by plasma cells . Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing four Ig-like constant domains (Cε1–Cε4). [ 1 ]

  4. Wikipedia : Osmosis/Type I hypersensitivity

    en.wikipedia.org/wiki/Wikipedia:Osmosis/Type_I...

    When the T-helper gets its hands on the antigen though, and also binds the costimulatory molecule, it’s now been primed, and the naive T-helper changes into a different sort of T-helper cell. Usually in type I hypersensitivity it differentiates into a type 2 T helper cell, or just TH2 cell, and this step happens in response to various small ...

  5. Hyperimmunoglobulin E syndrome - Wikipedia

    en.wikipedia.org/wiki/Hyperimmunoglobulin_E_syndrome

    An IgE level greater than 2,000 IU/mL is often considered diagnostic. [17] However, patients younger than 6 months of age may have very low to non-detectable IgE levels. Eosinophilia is also a common finding with greater than 90% of patients having eosinophil elevations greater than two standard deviations above the normal mean. [ 18 ]

  6. Basophil activation - Wikipedia

    en.wikipedia.org/wiki/Basophil_activation

    Immunoglobulin E is a class of antibody (or immunoglobulin "isotype") that has only been found in mammals. It plays an important role in allergy, and is especially associated with type 1 hypersensitivity. There are receptors (FcεR) for the constant region of IgE, the Fc region, on several types of cells, including Mast cells and Basophils ...

  7. Kimishige Ishizaka - Wikipedia

    en.wikipedia.org/wiki/Kimishige_Ishizaka

    While at Denver, the Ishizakas discovered the antibody class Immunoglobulin E (IgE) in 1966–1967 [10] [11] and its interplay with mast cells. [3] They demonstrated the IgE's critical role in mediating the release of histamine from mast cells. [2] The discovery of IgE is considered a milestone in immunology and the understanding of allergy. [2 ...

  8. Radioallergosorbent test - Wikipedia

    en.wikipedia.org/wiki/Radioallergosorbent_test

    The RAST is a radioimmunoassay test to detect specific IgE antibodies to suspected or known allergens for the purpose of guiding a diagnosis about allergy. [10] [11] IgE is the antibody associated with Type I allergic response: for example, if a person exhibits a high level of IgE directed against pollen, the test may indicate the person is allergic to pollen (or pollen-like) proteins.

  9. Anti-immunoglobulin - Wikipedia

    en.wikipedia.org/wiki/Anti-immunoglobulin

    Omalizumab is the drug therapy used to deliver the anti-immunoglobulin E antibodies. Omalizumab is a human anti-IgE monoclonal antibody. It blocks IgE-mediated reactions and reduces asthma symptoms by binding to free IgE antibodies in serum. The drug is delivered every 2-4 weeks depending on severity of the patient.

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