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Secondary sclerosing cholangitis (SSC) is a chronic cholestatic liver disease. SSC is a sclerosing cholangitis with a known cause. Alternatively, if no cause can be identified, then primary sclerosing cholangitis is diagnosed. SSC is an aggressive and rare disease with complex and multiple causes.
A 2–3:1 male-to-female predilection occurs in primary sclerosing cholangitis. [19] PSC can affect men and women at any age, although it is commonly diagnosed in the fourth decade of life, most often in the presence of IBD. [18]
The incidence of cholangiocarcinoma increases with age, and the disease is slightly more common in men than in women (possibly due to the higher rate of primary sclerosing cholangitis, a major risk factor, in men). [47] The prevalence of cholangiocarcinoma in people with primary sclerosing cholangitis may be as high as 30%, based on autopsy ...
Primary sclerosing cholangitis is a disorder of the bile ducts that presents with pruritus, ... Life expectancy without liver transplant is low, at most three years.
Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. [ 1 ] [ 2 ] [ 3 ] It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis .
In fetal and neonatal life the ductal plates are remodeled. The malformations can be atretic or fibrocystic. ... Primary sclerosing cholangitis; Hodgkin's lymphoma [2 ...
Up to 70-90% of people with primary sclerosing cholangitis have ulcerative colitis. [34] As many as 5% of people with UC may progress to develop primary sclerosing cholangitis. [ 28 ] [ 40 ] PSC is more common in men, and often begins between 30 and 40 years of age. [ 28 ]
Slightly reduced life expectancy [4] Frequency ~300 in 100,000 ... Liver, bile duct, and gallbladder conditions such as primary sclerosing cholangitis and cirrhosis. [1]
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