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Fenfluramine was an appetite suppressant which was used to treat obesity. [8] It was used both on its own and, in combination with phentermine, as part of the anti-obesity medication Fen-Phen. [8] In June 2020, fenfluramine was approved for medical use in the United States with an indication to treat Dravet syndrome. [7] [38]
Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed.
Dexfenfluramine, marketed as dexfenfluramine hydrochloride under the name Redux, is a serotonergic anorectic drug: it reduces appetite by increasing the amount of extracellular serotonin in the brain. [ 3 ] It is the d- enantiomer of fenfluramine and is structurally similar to amphetamine, but lacks any psychologically stimulating effects.
Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. [18] In 1997, after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. [19]
Fenfluramine was the main toxic component of the so-called ‘fen-phen’ combination. He led the renowned International Primary Pulmonary Hypertension Study (IPPHS), which was published in the prestigious New England Journal of Medicine in 1996, and which showed that fenfluramine had a causal role in primary pulmonary hypertension, a fatal ...
Carrots, celery, apples (no seeds!) and other crunchy fruits and veggies can work as dental treats, too. People With Pets shared this reminder about heartworm and other parasites, "Internal and ...
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Fenfluramine was sold as a racemic mixture of two enantiomers, dexfenfluramine and levofenfluramine. [ 12 ] [ 13 ] In 1994, sales of the combination drug Fen-phen ( fenfluramine and phentermine ) increased dramatically, as this combination produced substantial and apparent synergistic effect in promoting weight loss.