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In non-bullous cases, perivascular and interstitial neutrophils are sometimes present in the upper dermis, with damage to blood vessels An interface dermatitis with vacuolar alteration, not otherwise specified, may be caused by viral exanthems , phototoxic dermatitis , acute radiation dermatitis , erythema dyschromicum perstans , lupus ...
Mild superficial perivascular infiltrate of lymphocytes, histiocytes and occasional neutrophils. There is some exocytosis of inflammatory cells but not as prominent as in nummular dermatitis; Typical findings: [5] Psoriasiform hyperplasia, initially slight, with mild spongiosis; Usually numerous yeast-like organisms in the surface keratin
The term atopic dermatitis was coined in 1933 by Wise and Sulzberger. [95] Sulfur as a topical treatment for eczema was fashionable in the Victorian and Edwardian eras. [84] The word dermatitis is from the Greek δέρμα derma 'skin' and -ῖτις-itis 'inflammation' and eczema is from Greek: ἔκζεμα ekzema 'eruption'. [96]
Histology of the affected area commonly shows dense perivascular lymphocytic infiltration with reticulated degeneration of the epidermis. A study by Iwatsuki et al. detected Epstein–Barr virus (EBV) positive T-cells in the perivascular infiltration on biopsy in 28/29 patients tested. Antibody titers to EBV were measured in 14 of these ...
Causes of vacuolar interface dermatitis ; Main conditions [1] Characteristics Micrograph Photograph Generally/Not otherwise specified Typical findings, called "vacuolar interface dermatitis": [1] Mild inflammatory cell infiltrate along the dermoepidermal junction (black arrow in image) Vacuolization within the basal keratinocytes (white arrow ...
Treatments include systemic corticosteroids, dapsone, colchicine, hydroxychloroquine, and various immunosuppressant medications, such as methotrexate, mycophenolate, and azathioprine. Newer targeted medications, including omalizumab and belimumab , have also been used.
Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, [1] [2] is a skin disease characterized by the sudden onset of fever, an elevated white blood cell count, and tender, red, well-demarcated papules and plaques that show dense infiltrates by neutrophil granulocytes on histologic examination.
Perioral dermatitis, also known as periorificial dermatitis, is a common type of inflammatory skin rash. [2] Symptoms include multiple small (1–2 mm) bumps and blisters sometimes with background redness and scale, localized to the skin around the mouth and nostrils. Less commonly, the eyes and genitalia may be involved. [3]
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