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Only 1–2% of Alzheimer's cases are inherited due to autosomal dominant effects, as Alzheimer's is highly polygenic. When the disease is caused by autosomal dominant variants, it is known as early onset familial Alzheimer's disease, which is rarer and has a faster rate of progression. [17]
It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are inherited in an autosomal dominant manner. Most cases of early-onset Alzheimer's share the same traits as the "late-onset" form and are not caused by known genetic mutations.
However, because the only difference between the family members who developed Alzheimer's disease and those that did not in these families was the inheritance of the mutation in the amyloid gene, this suggested that the amyloid protein itself could cause the disease. The idea that amyloid could cause the disease influenced scientific research ...
Key risk factors for later-life dementia and Alzheimer’s disease are well-known: older age and biological sex at birth (women are more likely to get Alzheimer’s). Genetics also determine risk ...
Researchers say a subtype of gene known as APOE may be a factor in the inherited form of Alzheimer's and that this kind of the disease may be more common than previously thought
Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in the loss of neurons and synapses in the cerebral cortex and certain subcortical structures, resulting in gross atrophy of the temporal lobe, parietal lobe, and parts of the frontal cortex and cingulate gyrus. [14]
New research uncovers a genetic link between coronary artery disease and the development of Alzheimer's, ... heart — specifically the genetics that may link coronary artery disease and Alzheimer ...
Carol Joyce Jennings (née Bexon; 25 March 1954 – 29 March 2024) was a British campaigner and advocate for research into Alzheimer's disease.She served as an honorary Vice-President of the Alzheimer's Society until her death in 2024. [1]
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