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A fluorescence micrograph of cells in Drosophila larvae healing after a puncture wound. The arrow points to cells that have fused to form syncytia, and the arrowheads point to cells that are oriented to face the wound. [14] Wound healing is classically divided into hemostasis, inflammation, proliferation, and remodeling. Although a useful ...
A fibroblast is a type of biological cell typically with a spindle shape [1] that synthesizes the extracellular matrix and collagen, [2] produces the structural framework for animal tissues, and plays a critical role in wound healing. [3]
Histopathology of granulation tissue at 11 days after injury, showing fibroblasts, hemorrhage and lymphocytes. The extracellular matrix of granulation tissue is created and modified by fibroblasts. [5] Initially, it consists of a network of type-III collagen, a weaker form of the structural protein that can be produced rapidly.
When dermal fibroblasts express actin, the cells can slowly contract. This contraction plays a critical role in wound healing and fibrosis. By pulling tissues closed, differentiated myofibroblasts seal the skin after an injury (thereby, preventing infection but inducing scar formation). [4]
14089 Ensembl ENSG00000078098 ENSMUSG00000000392 UniProt Q12884 P97321 RefSeq (mRNA) NM_001291807 NM_004460 NM_007986 RefSeq (protein) NP_001278736 NP_004451 NP_032012 Location (UCSC) Chr 2: 162.17 – 162.25 Mb Chr 2: 62.33 – 62.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that ...
After healing is complete, these cells are lost through apoptosis and it has been suggested that in several fibrotic diseases (for example liver cirrhosis, kidney fibrosis, retroperitoneal fibrosis) that this mechanism fails to work, leading to persistence of the myofibroblasts, and consequently expansion of the extracellular matrix (fibrosis ...
A week after the injury, the edges of the wound are pulled together by contraction. Contraction is an important part of the healing process when damage has been extensive, and involves shrinking in size of underlying contractile connective tissue, which brings the wound margins toward one another. [1]
Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue.
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