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  2. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    Simply switching the patient from 40 mg of morphine to 10 mg of levorphanol would be dangerous due to dose accumulation, and hence frequency of administration should also be taken into account. There are other concerns about equianalgesic charts. Many charts derive their data from studies conducted on opioid-naive patients.

  3. Ibuprofen - Wikipedia

    en.wikipedia.org/wiki/Ibuprofen

    The correlation between the severity of symptoms and measured ibuprofen plasma levels is weak. Toxic effects are unlikely at doses below 100 mg/kg, but can be severe above 400 mg/kg (around 150 tablets of 200 mg units for an average adult male); [47] however, large doses do not indicate the clinical course is likely to be lethal. [48]

  4. Median lethal dose - Wikipedia

    en.wikipedia.org/wiki/Median_lethal_dose

    In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.

  5. Ibuprofen (Advil or Motrin), naproxen (Aleve) and aspirin (Bayer or Ecotrin) are common pain relievers that belong to a class of medication called non-steroidal anti-inflammatory drugs (NSAIDs).

  6. Lethal dose - Wikipedia

    en.wikipedia.org/wiki/Lethal_dose

    The median infective dose (ID 50) is the number of organisms received by a person or test animal qualified by the route of administration (e.g., 1,200 org/man per oral). Because of the difficulties in counting actual organisms in a dose, infective doses may be expressed in terms of biological assay, such as the number of LD 50 's

  7. Acceptable daily intake - Wikipedia

    en.wikipedia.org/wiki/Acceptable_Daily_Intake

    Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]

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  9. Reference dose - Wikipedia

    en.wikipedia.org/wiki/Reference_dose

    Subsequently, the National Academy of Sciences (NAS) reviewed the health implications of perchlorate, and in 2005 proposed a much higher alternative reference dose of 0.0007 mg/kg/day based primarily on a 2002 study by Greer et al. [6] During that study, 37 adult human subjects were split into four exposure groups exposed to 0.007 (7 subjects ...

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