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[9] [10] Inside the transcriptomes of glandular trichomes in the cannabis plant, the pathway for cannabinoid production takes place. [9] Beginning with the formation of 3,5,7-trioxododecaneoyl-COA by the condensation reaction between hexanoyl-CoA and malonyl-CoA , catalyzed by type III polyketide synthase (PKS), the product is then used to form ...
THCA synthase is expressed in the glandular trichomes of Cannabis sativa. THCA synthase may contribute to the self-defense of Cannabis plants by producing THCA and hydrogen peroxide, which are both cytotoxic. Because these products are toxic to the plant, THCA synthase is secreted into the trichome storage cavity. [7]
Cannabis and cancer risk. The cannabis plant contains more than 100 cannabinoids, including THC and CBD, and hundreds of non-cannabinoid chemicals. Scientists are just beginning to understand the ...
Although cannabis is legalized for medical uses in more than half of the states of the United States, no products have been approved for federal commerce by the Food and Drug Administration, a status that limits cultivation, manufacture, distribution, clinical research, and therapeutic applications.
Kief (from Arabic كيف kīf, "Joy, pleasure" [1] [2]), sometimes transliterated as keef, also known as "Dust" and "Chief" a.k.a cannabis crystals among other names, refers to the pure and clean collection of loose cannabis trichomes, which are accumulated by being sifted from cannabis flowers or buds with a mesh screen or sieve.
The American Cancer Society [154] and American Psychological Association [155] have noted the obstacles that exist for conducting research on cannabis, and have called on the federal government to better enable scientific study of the drug. Cancer Research UK say that while cannabis is being studied for therapeutic potential, "claims that there ...
Dronabinol (brand names Marinol and Syndros) is a delta-9-THC containing drug for treating HIV/AIDS-induced anorexia and chemotherapy-induced nausea and vomiting. [58] The CBD drug Epidiolex has been approved by the Food and Drug Administration for treatment of two rare and severe forms of epilepsy, [59] Dravet and Lennox-Gastaut syndromes. [60]
A 2012 review examining the relation of cancer and cannabis found little direct evidence that cannabinoids found in cannabis, including THC, are carcinogenic. Cannabinoids are not mutagenic according to the Ames test. However, cannabis smoke has been found to be carcinogenic in rodents and mutagenic in the Ames test.