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Hypertrophic cardiomyopathy (HCM, or HOCM when obstructive) is a condition in which muscle tissues of the heart become thickened without an obvious cause. [8] The parts of the heart most commonly affected are the interventricular septum and the ventricles . [ 10 ]
Mavacamten, sold under the brand name Camzyos, is a medication used to treat obstructive hypertrophic cardiomyopathy. [8] [9] Mavacamten is a small-molecule allosteric [10] and cardiac myosin inhibitor. [8] It was developed by MyoKardia, a subsidiary of Bristol Myers Squibb. [11]
Restrictive cardiomyopathy may be caused by amyloidosis, hemochromatosis, and some cancer treatments. [4] Broken heart syndrome is caused by extreme emotional or physical stress. [3] Treatment depends on the type of cardiomyopathy and the severity of symptoms. [5] Treatments may include lifestyle changes, medications, or surgery. [5]
Hypertrophic cardiomyopathy (HCM) is a condition where some of the heart muscle becomes too thick, (a.k.a., hypertrophied, a typical diagnostic criterion is a 15 millimeters or greater left ...
Septal myectomy is associated with a low perioperative mortality and a high late survival rate. A study at the Mayo Clinic found surgical myectomy performed to relieve outflow obstruction and severe symptoms in HCM was associated with long-term survival equivalent to that of the general population, and superior to obstructive HCM without operation.
People with heart failure, also known as congestive heart failure (CHF), are educated to undertake various non-pharmacological measures to improve symptoms and prognosis. Such measures include: [2] Moderate physical activity, when symptoms are mild or moderate; or bed rest when symptoms are severe. In individuals with heart failure, increasing ...
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MYK-224 is a small-molecule cardiac myosin inhibitor developed by Bristol Myers Squibb for hypertrophic cardiomyopathy. [1] [2] [3] References
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