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Clobetasol is believed to work by activating steroid receptors. [8] Clobetasol propionate was patented in 1968 and came into medical use in 1978. [13] It is available as a generic medication. [10] In 2022, it was the 156th most commonly prescribed medication in the United States, with more than 3 million prescriptions. [14] [15]
Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate , has also been marketed, and is far more widely used in comparison. [ 2 ] [ 3 ]
Moderate steroids are used for atopic dermatitis, nummular eczema, xerotic eczema, lichen sclerosis et atrophicus of the vulva, scabies (after scabiecide) and severe dermatitis. Strong steroids are used for psoriasis , lichen planus , discoid lupus , chapped feet, lichen simplex chronicus , severe poison ivy exposure, alopecia areata , nummular ...
Lichen sclerosus; Other names: Balanitis xerotica obliterans, lichen sclerosus et atrophicus, [1] Lichen sclerosis et atrophicus, [2] lichen plan atrophique, lichen plan scléreux, Kartenblattförmige Sklerodermie, Weissflecken Dermatose, lichen albus, lichen planus sclerosus et atrophicus, dermatitis lichenoides chronica atrophicans, kraurosis vulvae [3]
Note the propionate groups at the C17α and C21α positions (top right corner). This is a list of corticosteroid esters , including esters of steroidal glucocorticoids and mineralocorticoids . [ 1 ] [ 2 ] [ 3 ]
Lichen planus may be categorized as affecting mucosal or cutaneous surfaces.. Cutaneous forms are those affecting the skin, scalp, and nails. [10] [11] [12]Mucosal forms are those affecting the lining of the gastrointestinal tract (mouth, pharynx, esophagus, stomach, anus), larynx, and other mucosal surfaces including the genitals, peritoneum, ears, nose, bladder and conjunctiva of the eyes.
Examples include lichen planus, lichen sclerosus and lichen nitidus. It can also be associated with abrasion or drug use. [2] It has been observed in conjunction with the use of proton pump inhibitors, and might be a sign and/or symptom of lupus such as subacute cutaneous lupus erythematous, according to the case reports and reviews. [3] [4] [5 ...
Lichen nitidus is a chronic inflammatory disease of unknown cause [1] characterized by 1–2 mm, discrete and uniform, shiny, flat-topped, pale flesh-colored or reddish-brown papules [2] [3] that may appear as hypopigmented against dark skin.