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2. HMG-CoA reductase - Wikipedia

   en.wikipedia.org/wiki/HMG-CoA_reductase

   This enzyme is the target of the widely available cholesterol-lowering drugs known collectively as the statins, which help treat dyslipidemia. HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum , and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain ...

3. Statin - Wikipedia

   en.wikipedia.org/wiki/Statin

   Statins (or HMG-CoA reductase inhibitors) are a class of medications that lower cholesterol. They are prescribed typically to people who are at high risk of cardiovascular disease . [ 1 ]

4. Pick Your Poison: Overweight or High Cholesterol

   www.aol.com/news/2013-05-19-pick-your-poison...

   The study, published in the Journal of the American College of Cardiology, used Merck's Zocor, but it seems safe to assume that other statins -- Pfizer's Lipitor and AstraZeneca's Crestor -- would ...

5. Cardiovascular agents - Wikipedia

   en.wikipedia.org/wiki/Cardiovascular_agents

   Most efficacious in lowering LDL-C levels, statins block the action of HMG-CoA reductase through competitive inhibition. [18] HMG-CoA reductase, an enzyme found in hepatocytes, is responsible for the conversion of HMG-CoA to mevalonic acid for cholesterol biosynthesis. Inhibition of this enzyme reduces the synthesis and thus, availability of ...

6. When a Good Idea Goes Bad - AOL

   www.aol.com/news/2011-09-02-when-a-good-idea...

   Give AstraZeneca (NYS: AZN) credit for attempting to differentiate Crestor as the cholesterol drug market is about to get flooded with generic versions of Pfizer's (NYS: PFE) top-selling Lipitor.

7. AstraZeneca's Crestor Fails to Best Lipitor in Study - AOL

   www.aol.com/2011/09/02/astrazenecas-crestor...

   AstraZeneca (NYS: AZN) just lost a potential marketing edge for Crestor. In trial results announced today, the statin drug failed to best Lipitor at clearing clogged arteries, at least in a ...

8. Atorvastatin - Wikipedia

   en.wikipedia.org/wiki/Atorvastatin

   Atorvastatin is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. [4] For the prevention of cardiovascular disease, statins are a first-line treatment. [4] It is taken by mouth. [4] Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains. [4]

9. AZ's Crestor Scored Points, but Didn't Beat Lipitor - AOL

   www.aol.com/2011/11/15/azs-crestor-scored-points...

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