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The DRKS is an open access, free of charge online register for clinical trials and is available both in English and German. DRKS is part of the WHO's ICTRP. The DRKS works with two partner registries in Germany, DeReG (German Registry for Somatic Gene-Transfer Trials) and Clinical Trial Registry of the University Medical Center Freiburg. [4]
CENTRAL is a database that contains details of articles of controlled trials and other studies of healthcare interventions from bibliographic databases (majorly MEDLINE and EMBASE), and other published and unpublished sources that are difficult to access, including trials from the trial registries such as International Clinical Trials Registry ...
Heart Protection Study - a randomized controlled trial that studied the cholesterol-lowering drug simvastatin and vitamin supplementation in people at risk of cardiovascular disease. [16] JUPITER trial - a randomized controlled trial to evaluate whether statins reduce heart attacks and strokes in people with normal cholesterol levels. [17]
By Christy Santhosh (Reuters) -The U.S. health regulator has placed a clinical hold on Iovance Biotherapeutics' trial of its experimental cell therapy in lung cancer patients after a patient death ...
A new study compares the benefits and risks of taking GLP-1 medications for weight loss, including risks of dementia, addiction, heart disease, and gastrointestinal problems, among others.
[148] [149] Potti's misconduct resulted in the suspension of three clinical trials based on his research and a lawsuit filed against Duke by patients enrolled in those studies. [150] As of 2021 Potti has had 11 of their research publications retracted, and one other paper has received an expression of concern. [151] [152]
No improvement in clinical benefit; risk for death; veno-occlusive disease. [2] Pemoline (Cylert) 1997 Canada, UK Withdrawn from US in 2005 due to hepatotoxicity. [41] [3] Pentobarbital: 1980 Norway Risk of fatal overdose. [3] Pentylenetetrazol: 1982 US Withdrawn for inability to produce effective convulsive therapy, and for causing seizures.
An outcome is the goal of the clinical trial, such as survival after five years for cancer treatment. Outcome switching can lead to bias and undermine the reliability of the trial, for instance when outcomes are switched after researchers already have access to trial data.