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The word liposome derives from two Greek words: lipo ("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid.. Liposomes were first described by British hematologist Alec Douglas Bangham [10] [11] [12] in 1961 at the Babraham Institute, in Cambridge—findings that were published 1964.
The Journal of Liposome Research is a peer-reviewed academic journal that publishes original research on the topics of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry.
A ligand-targeted liposome (LTL) is a nanocarrier with specific ligands attached to its surface to enhance localization for targeted drug delivery. The targeting ability of LTLs enhances cellular localization and uptake of these liposomes for therapeutic or diagnostic purposes.
The use of cationic lipids helps to enhance the overall stability and efficiency of liposomes. Although cationic lipids themselves are able to encapsulate nucleic acids into liposomes, the transfection efficiency is low due to a process known as endosomal escape.
Solid lipid nanoparticles can function as the basis for oral and parenteral drug delivery systems. SLNs combine the advantages of lipid emulsion and polymeric nanoparticle systems while overcoming the temporal and in vivo stability issues that troubles the conventional as well as polymeric nanoparticles drug delivery approaches. [10]
Liposomal medicine research for cancer therapy has increased over the years as an alternative to conventional cancer treatment. [15] There is an interest in liposomal medicine because it features targeted drug delivery while mitigating the damage to healthy cells and tissues. [ 15 ]
(Note- the term “liposome” is in essence synonymous with “vesicle” except that vesicle is a general term for the structure whereas liposome refers to only artificial not natural vesicles) The basic idea of liposomal drug delivery is that the drug is encapsulated in solution inside the liposome then injected into the patient. These drug ...
A liposome extruder is a device that prepares cell membranes, exosomes and also generates nanoscale liposome formulations. [ 1 ] [ 2 ] The liposome extruder employs the track-etched membrane to filter huge particles and achieve sterile filtration.