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The development of stimuli-responsive drug carriers was not popularized until the mid-1980s by researchers at Utah University, who created thermally-responsive drug delivery systems. [4] Since the eruption of this field, substantial research has been conducted to tune stimuli-responsive drug delivery systems despite several limitations.
Ultrasound-triggered drug delivery using stimuli-responsive hydrogels refers to the process of using ultrasound energy for inducing drug release from hydrogels that are sensitive to acoustic stimuli. This method of approach is one of many stimuli-responsive drug delivery-based systems that has gained traction in recent years due to its ...
This method of drug delivery falls in the category of stimuli-responsive drug delivery systems which include pH, temperature, and redox-responsive systems. Mechanical forces occur naturally throughout the human body therefore, stretch-triggered drug delivery systems may be used to autonomously deliver medications to the body when needed.
Additionally, drug-loaded particles within the hydrogel have been proposed as dual-stimuli responsive drug delivery systems combining pH-responsivity with the temperature response of the PEGylated polyester gels. Studies show that these types of hydrogels can be used to treat tumors in lungs and bladders. [19]
These smart drug delivery systems are able to deliver the drug with minimal leakage, can be actively or passively targeted to different areas within the body, and will only release drug in the presence of certain triggers, creating a sustained local response and accumulation of drug at the disease area.
Drug delivery systems have been around for many years, but there are a few recent applications of drug delivery that warrant 1. Drug delivery to the brain: Many drugs can be harmful when administered systemically; the brain is very sensitive to medications and can easily cause damage if a drug is administered directly into the bloodstream.
Controlled drug release systems can be achieved through several methods. Rate-programmed drug delivery systems are tuned to the diffusivity of active agents across the membrane. [44] Another delivery-release mechanism is activation-modulated drug delivery, where the release is triggered by environmental stimuli.
Self-microemulsifying drug delivery system; Shampoo; Silicone gel sheeting; Sink condition; Small molecule drug conjugate; Smoking; Softgel; Solution (chemistry) Sonophoresis; Stimuli-responsive drug delivery systems; Stretch-triggered drug delivery; Suppository; Suspension (chemistry) Modified-release dosage; Syrette; Syringe