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Vibegron, sold under the brand name Gemtesa, is a medication for the treatment of overactive bladder. [1] [5] [6] Vibegron is a selective beta-3 adrenergic receptor agonist. [1] The most common side effects include headache, urinary tract infection, common cold, diarrhea, nausea, and upper respiratory tract infection. [5]
Common side effects include high blood pressure, headaches, and urinary tract infections. [5] Other significant side effects include urinary retention , irregular heart rate , and angioedema . [ 5 ] [ 7 ] It works by activating the β 3 adrenergic receptor in the bladder , resulting in its relaxation.
The chemical structure of vibegron, a β 3-adrenergic receptor agonist. In 2018 two other β 3-AR agonists are in clinical trials, vibegron and solabegron. Vibegron is in phase 3 clinical trial and is used to treat OAB. [3] Solabegron is in phase 2b clinical trials to treat OAB in women and in phase 1 clinical trials in men to treat OAB. [4] [5]
Overactive bladder (OAB) is a common condition where there is a frequent feeling of needing to urinate to a degree that it negatively affects a person's life. [2] The frequent need to urinate may occur during the day, at night, or both. [4]
Solabegron (code name GW-427,353) is a drug which acts as a selective agonist for the β 3 adrenergic receptor.It is being developed for the treatment of overactive bladder and irritable bowel syndrome.
Darifenacin (trade name Enablex in United States and Canada, Emselex in the European Union) is a medication used to treat urinary incontinence due to an overactive bladder. [1] [2] [3] It was discovered by scientists at the Pfizer research site in Sandwich, UK under the identifier UK-88,525 and used to be marketed by Novartis.
Side effects of midodrine include hypertension (high blood pressure), paresthesia, itching, goosebumps, chills, urinary urgency, urinary retention, and urinary frequency. [3] Midodrine is a prodrug of its active metabolite desglymidodrine. [3] [1] This metabolite acts as a selective agonist of the α 1-adrenergic receptor.
The most common side effects include upper respiratory tract infections, urinary tract infections, pharyngitis, sinusitis, nasopharyngitis, headache, cough, oropharyngeal pain, constipation and dry mouth. [4] In 2022, it was the 211th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [7] [8]
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