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Vibegron, sold under the brand name Gemtesa, is a medication for the treatment of overactive bladder. [1] [5] [6] Vibegron is a selective beta-3 adrenergic receptor agonist. [1] The most common side effects include headache, urinary tract infection, common cold, diarrhea, nausea, and upper respiratory tract infection. [5]
Urovant Sciences, a wholly-owned subsidiary of Sumitovant Biopharma Ltd, announced the publication of a new review of data on Gemtesa (vibegron) 75 mg in the peer-reviewed journal, Therapeutics ...
The chemical structure of vibegron, a β 3-adrenergic receptor agonist. In 2018 two other β 3-AR agonists are in clinical trials, vibegron and solabegron. Vibegron is in phase 3 clinical trial and is used to treat OAB. [3] Solabegron is in phase 2b clinical trials to treat OAB in women and in phase 1 clinical trials in men to treat OAB. [4] [5]
Food is known to increase the absorption of Invega type ER OROS prolonged-release tablets. Food increased exposure of paliperidone by up to 50-60%, however, half-life was not significantly affected. The effect was probably due to a delay in the transit of the ER OROS formulation in the upper part of the GI channel, resulting in increased ...
Mirabegron, sold under the brand name Myrbetriq among others, is a medication used to treat overactive bladder. [5] Its benefits are similar to antimuscarinic medication such as solifenacin or tolterodine. [6]
Darifenacin (trade name Enablex in United States and Canada, Emselex in the European Union) is a medication used to treat urinary incontinence due to an overactive bladder. [1] [2] [3] It was discovered by scientists at the Pfizer research site in Sandwich, UK under the identifier UK-88,525 and used to be marketed by Novartis.
β 1-Adrenergic receptor agonists, also known as beta-1 agonists, are a class of drugs that bind selectively to the β 1-adrenergic receptor.As a result, they act more selectively upon the heart. β-Adrenoceptors typically bind to norepinephrine release by sympathetic adrenergic nerves and to circulating epinephrine.
The main medical use for pizotifen is for the prevention of migraine and cluster headache.Pizotifen is one of a range of medications used for this purpose, other options include propranolol, topiramate, valproic acid, cyproheptadine and amitriptyline.