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Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. [ 5 ] [ 6 ] TfR1 is required for iron import from transferrin into cells by endocytosis .
TfR2 binds to transferrin with a 25-30 fold lower affinity than TfR1. [3] [4] Although TfR1 mediated iron uptake is the major pathway for iron acquisition by most cells and especially developing erythrocytes, several studies have indicated that the uptake mechanism varies depending upon the cell type. It is also reported that Tf uptake exists ...
Each monomer consists of three domains: the protease, the helical, and the apical domains. The shape of a transferrin receptor resembles a butterfly based on the intersection of three clearly shaped domains. [18] Two main transferrin receptors found in humans denoted as transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2).
Most cell types take up iron primarily through receptor-mediated endocytosis via transferrin receptor 1 (TFR1), transferrin receptor 2 (TFR2) and GAPDH. TFR1 has a 30-fold higher affinity for transferrin-bound iron than TFR2 and thus is the main player in this process.
Most cell types take up iron primarily through receptor-mediated endocytosis via transferrin receptor 1 (TFR1), transferrin receptor 2 (TFR2) and GAPDH. TFR1 has a 30-fold higher affinity for transferrin-bound iron than TFR2 and thus is the main player in this process.
Transferrin receptor (Transferrin receptor protein 1 - TfR1), mediates cellular uptake of iron. Ubiquitously expressed on dividing, normal (haematological precursors) and malignant cells. Currently investigated as a target for an antibody ("probody") drug conjugate from Cytomx / Abbvie to treat various cancers. CD72
The term death receptor refers to those members of the TNF receptor superfamily that contain a death domain, such as TNFR1, Fas receptor, DR4 and DR5. [4] They were named after the fact that they seemed to play an important role in apoptosis (programmed cell death), although they are now known to play other roles as well.
8797 21933 Ensembl ENSG00000104689 ENSMUSG00000022074 UniProt O00220 Q9QZM4 RefSeq (mRNA) NM_003844 NM_020275 RefSeq (protein) NP_003835 NP_064671 Location (UCSC) Chr 8: 23.19 – 23.23 Mb Chr 14: 70 – 70.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A ...