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HLRCC is an autosomal dominant condition caused by a mutation in the FH gene, which results in dysfunction of the citric acid cycle, leading to an accumulation of fumarate. [7] [12] The fumarate hydratase gene is located on the long arm of chromosome 1 (1q42.3-43), spans 22 kilobases and has 10 exons; the first exon codes for a signal peptide.
Leiomyoma enucleated from a uterus. External surface on left; cut surface on right. Micrograph of a small, well-circumscribed colonic leiomyoma arising from the muscularis mucosae and showing fascicles of spindle cells with eosinophilic cytoplasm and elongated, cigar-shaped nuclei Immunohistochemistry for β-catenin in uterine leiomyoma, which is negative as there is only staining of cytoplasm ...
M8890/0 Leiomyoma, NOS Fibroid uterus (C55.9) Fibromyoma; Leiomyofibroma; Plexiform leiomyoma; Lipoleiomyoma; M8890/1 Leiomyomatosis, NOS Intravascular leiomyomatosis; M8890/3 Leiomyosarcoma, NOS M8891/0 Epithelioid leiomyoma Leiomyoblastoma; M8891/3 Epithelioid leiomyosarcoma M8892/0 Cellular leiomyoma M8893/0 Bizarre leiomyoma
Angioleiomyoma (vascular leiomyoma, angiomyoma) of the skin is thought to arise from vascular smooth muscle, and is generally acquired. [3] Angioleiomyomas appear as small (<2 cm), firm, movable, slow growing subcutaneous nodules. Pain is a common symptom. They are most commonly seen on the extremities. The cause of angioleiomyoma is unknown.
If 5 or more mitotic figures are present in 10 high powered fields but the behavior still appears benign, may append “with significant mitotic activity”. Moderate to severe atypia without tumor cell necrosis atypical leiomyoma if < 10 mitotic figures per high power field or; leiomyosarcoma if ≥ 10 mitotic figures per high power field
Cutaneous leiomyoma, also known as leiomyoma cutis, [1] or cutaneous leiomyomata, [2] is a benign skin tumor made of smooth muscle cells. [3] There are three different types of cutaneous leiomyomas, genital leiomyomas, angioleiomyomas, and piloleiomyomas. Cutaneous leiomyomas can occur sporadically or as a part of a genetic condition.
Whether or not angiomyomas are a type of leiomyoma or a separate entity is disputed as of 2014. [3] Myomas are benign tumors of the uterus that can affect the fertility of a woman depending mainly on three factors: Size (cut off value 4-5 cm) Number; Location (they can be intramural, subserous or submucous).
Ultrasound and imaging procedures are used to diagnose genital leiomyomas, while surgically removing the tumor is the most common treatment of these diseases. Case studies for nipple areolar, scrotal, and uterine leiomyoma were used, since there were not enough secondary resources to provide more evidence.