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The human gallbladder is a hollow grey-blue organ that sits in a shallow depression below the right lobe of the liver. [2] In adults, the gallbladder measures approximately 7 to 10 centimetres (2.8 to 3.9 inches) in length and 4 centimetres (1.6 in) in diameter when fully distended. [3]
Most people with gallstones (about 80%) are asymptomatic. [ 2 ] [ 3 ] However, when a gallstone obstructs the bile duct and causes acute cholestasis , a reflexive smooth muscle spasm often occurs, resulting in an intense cramp -like visceral pain in the right upper part of the abdomen known as a biliary colic (or "gallbladder attack"). [ 4 ]
In the developed world, 10 to 15% of adults have gallstones. [3] Of those with gallstones, biliary colic occurs in 1 to 4% each year. [3] Nearly 30% of people have further problems related to gallstones in the year following an attack. [3] About 15% of people with biliary colic eventually develop inflammation of the gallbladder if not treated. [3]
Gallbladder diseases are diseases involving the gallbladder and is closely linked to biliary disease, with the most common cause being gallstones (cholelithiasis). [1] [2]The gallbladder is designed to aid in the digestion of fats by concentrating and storing the bile made in the liver and transferring it through the biliary tract to the digestive system through bile ducts that connect the ...
In addition, past the small intestine (which is normally responsible for absorbing fat from food) the gastrointestinal tract and gut flora are not adapted to processing fats, leading to problems in the large intestine. [16] The cholesterol contained in bile will occasionally accrete into lumps in the gallbladder, forming gallstones. Cholesterol ...
Most people with gallstones do not have symptoms. [1] However, when a gallstone temporarily lodges in the cystic duct, they experience biliary colic. [1] Biliary colic is abdominal pain in the right upper quadrant or epigastric region. It is episodic, occurring after eating greasy or fatty foods, and leads to nausea and/or vomiting. [13]
Synthesis of bile acids is a major route of cholesterol metabolism in most species other than humans. The body produces about 800 mg of cholesterol per day and about half of that is used for bile acid synthesis producing 400–600 mg daily. Human adults secrete between 12 and 18 g of bile acids into the intestine each day, mostly after meals.
Alternatively, where a suitable head of water is not available, pumped-storage hydroelectricity or other forms of grid energy storage such as compressed air energy storage and thermal energy storage can store energy developed by high-wind periods and release it when needed. The type of storage needed depends on the wind penetration level ...
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