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Aziridine is an organic compound consisting of the three-membered heterocycle C 2 H 5 N. [5] [6] It is a colorless, toxic, volatile liquid that is of significant practical interest. [7] Aziridine was discovered in 1888 by the chemist Siegmund Gabriel. [8] Its derivatives, also referred to as aziridines, are of broader interest in medicinal ...
Mitomycin C, an aziridine, is used as a chemotherapeutic agent by virtue of its antitumour activity. [1]In organic chemistry, aziridines are organic compounds containing the aziridine functional group (chemical structure (R−) 4 C 2 N−R), a three-membered heterocycle with one amine (>NR) and two methylene bridges (>CR 2).
Aziridiniums are the ionic form of the class of molecules known as aziridines. [1] Aziridines can be used to insert nitrogen atoms during synthesis, but without any substituents attached to the nitrogen in the ring, they are considered nonactivated and inert. [2] They can be rendered active by the preparation of aziridinium ions.
The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. [1] [2] They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C, its international nonproprietary name. Mitomycin C is used as a medicine ...
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Azirines are three-membered heterocyclic unsaturated (i.e. they contain a double bond) compounds containing a nitrogen atom and related to the saturated analogue aziridine. [1] They are highly reactive yet have been reported in a few natural products such as Dysidazirine .
Polyethylenimine (PEI) or polyaziridine is a polymer with repeating units composed of the amine group and two carbon aliphatic CH 2 CH 2 spacers. Linear polyethyleneimines contain all secondary amines, in contrast to branched PEIs which contain primary, secondary and tertiary amino groups.
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