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The organic compound citrulline is an α-amino acid. [2] Its name is derived from citrullus, the Latin word for watermelon.Although named and described by gastroenterologists since the late 19th century, it was first isolated from watermelon in 1914 by Japanese researchers Yatarō Koga (古賀彌太郎) and Ryō Ōtake (大嶽了) [3] [4] and further codified by Mitsunori Wada of Tokyo ...
In a 2017 scientific review, researchers found that L-citrulline supplementation may increase nitric oxide levels, reduce blood pressure, and improve flow to blood vessels.
These diuretic foods and drinks could help. ... “It also has citrulline, an amino acid that helps ‘relax’ blood vessels and helps prevent water from going into the surrounding tissues ...
Citrulline may increase levels of nitric oxide, which helps blood vessels to expand and lowers blood pressure as well. This amino acid can also help with muscle recovery, providing relief for ...
The amino acid citrulline is produced in watermelon rind. [31] [32] Varieties. ... The variety was an important food source for travellers in the Kalahari Desert.
Homocitrulline has been suggested as a confounding antigen for rheumatoid arthritis antibodies targeting citrullinated proteins/peptides. [1] Antibodies binding to homocitrulline-containing sequences have been found in rheumatoid arthritis patients' sera [2] [3] More recently, it has been shown that homocitrulline-containing proteins are present in rheumatoid arthritis (RA) joints. [4]
One source recommends an L-citrulline dosage of 2,000 milligrams three times a day, or 1.76 grams of citrulline malate for every 1 gram of citrulline you might take for circulatory health.
Citrulline is not one of the 20 standard amino acids encoded by DNA in the genetic code. Instead, it is the result of a post-translational modification. Citrullination is distinct from the formation of the free amino acid citrulline as part of the urea cycle or as a byproduct of enzymes of the nitric oxide synthase family.
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