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The main toxin of curare, d-tubocurarine, occupies the same position on the receptor as ACh with an equal or greater affinity, and elicits no response, making it a competitive antagonist. The antidote for curare poisoning is an acetylcholinesterase (AChE) inhibitor (anti-cholinesterase), such as physostigmine or neostigmine. By blocking ACh ...
Pot curare was generally a mixture of extracts from various genera in the families Menispermaceae and Strychnaceae. The tripartite classification into "tube", "calabash", and "pot" curares early became untenable, due to inconsistencies in the use of the different types of vessels and the complexities of the dart poison recipes themselves.
The effect with which injected curare poison is usually associated is muscle paralysis and resultant death. [87] Curare notably functions to inhibit nicotinic acetylcholine receptors at the neuromuscular junction. Normally, these receptor channels allow sodium ions into muscle cells to initiate an action potential that leads to muscle contraction.
Curare acts as a neuromuscular blocking agent that induces flaccid paralysis. This poison binds to the acetylcholine (ACh) receptors on the muscle, blocking them from binding to ACh. As a result, ACh accumulates within the neuromuscular junction, but since ACh cannot bind to the receptors on the muscle, the muscle cannot be stimulated.
While curare, the naturally occurring antinicotinics derived from Chondrodendron and Strychnos, was a poison used by South American Indians for hunting. [ 1 ] [ 3 ] [ 4 ] According to their site of actions, cholinergic blocking drugs can be classified into two general types — antimuscarinic and antinicotinic agents. [ 1 ]
What are the symptoms of carbon monoxide poisoning? In high concentrations, it can be deadly. The acute effects arise from carboxyhemoglobin formation in the blood, which hampers oxygen absorption.
She had noted that the symptoms and signs of myasthenia were similar to those found in curare poisoning, and physostigmine was used as an antidote to curare poisoning at that time. [24] Her article explaining the first case of myasthenia gravis being successfully treated with physostigmine was published in The Lancet in June 1934. [25]
Suspected mushroom poisoning in Australia has made headlines around the world