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The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.
Thanks to early detection and treatment, rates of cervical cancer have plummeted by more than half over the past 50 years. ... Too old for HPV vaccination? Among women in their 30s and early 40s ...
A wide variety of HPV types can cause genital warts, but types 6 and 11 together account for about 90% of all cases. [35] [36] However, in total more than 40 types of HPV are transmitted through sexual contact and can infect the skin of the anus and genitals. [4] Such infections may cause genital warts, although they may also remain asymptomatic.
Human papillomavirus (HPV) infection is a cause of nearly all cases of cervical cancer. [6] Most women will successfully clear HPV infections within 18 months. Those that have a prolonged infection with a high-risk type (e.g. types 16, 18, 31, 45) are more likely to develop Cervical Intraepithelial Neoplasia, due to the effects that HPV has on ...
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A 2007 survey of American women found 40% had heard of HPV infection and less than half of those knew it causes cervical cancer. [175] Over a longitudinal study from 1975 to 2000, it was found that people of lower socioeconomic census brackets had higher rates of late-stage cancer diagnosis and higher morbidity rates.
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