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Fenofibrate (sold under the brand name Tricor among others), is an oral medication of the fibrate class used to treat abnormal blood lipid levels. [3] It is less commonly used compared to statins because it treats a different type of cholesterol abnormality to statins.
It reduces total blood cholesterol by blocking the action of 3-hydroxy-3-methyl-glutaryl-coenzyme-A (HMG-CoA) reductase, an enzyme in the liver involved in the production of cholesterol. [2] As the liver needs cholesterol to produce bile, the reduced blood cholesterol level causes the liver cells to produce receptors that draw cholesterol from ...
In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis, idiosyncratic destruction of muscle tissue, leading to kidney failure. The less lipophilic statins are less prone to cause this reaction, and are probably safer to be combined with fibrates than the more lipophilic statins are. Drug toxicity includes acute ...
Fenofibrate: Fibrate: Simvastatin: Statin: ... medication used to treat abnormal blood lipid levels when used in combination with a low-fat diet and ...
ATC code C10 Lipid modifying agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Gemfibrozil, sold under the brand name Lopid among others, is a medication used to treat abnormal blood lipid levels. [3] It is generally less preferred than statins. [3] [4] Use is recommended together with dietary changes and exercise. [3] It is unclear if it changes the risk of heart disease. [3] It is taken by mouth. [3]
Like other statins, atorvastatin also reduces blood levels of triglycerides and slightly increases levels of HDL-cholesterol. In people with acute coronary syndrome, high-dose atorvastatin treatment may play a plaque-stabilizing role. [97] [98] At high doses, statins have anti-inflammatory effects, incite reduction of the necrotic plaque core ...
Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. [6] It is recommended to be used together with dietary changes, exercise, and weight loss. [6] It is taken orally (by mouth). [6]
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