Search results
Results from the WOW.Com Content Network
Limits for short-term exposure, such as STELs or CVs, are defined only if there is a particular acute toxicity associated with a substance. These limits are set by the American Conference of Governmental Industrial Hygienists (ACGIH) and the Occupational Safety and Health Administration (OSHA), based on experimental data.
In toxicology, the lowest published toxic dose (Toxic Dose Low, TD Lo) is the lowest dosage per unit of bodyweight (typically stated in milligrams per kilogram) of a substance known to have produced signs of toxicity in a particular animal species. [1]
Extreme doses may result in a respiratory depression, coma, or death. [3] Complications may include seizures, aspiration pneumonia, low blood sugar, and injuries or self-harm such as suicide. [3] [4] Alcohol intoxication can lead to alcohol-related crime with perpetrators more likely to be intoxicated than victims. [12]
Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties. [36] [37] Prednisone is a prodrug; it is metabolised in the liver by 11-β-HSD to prednisolone, the active drug. Prednisone has no substantial biological effects until converted via hepatic metabolism to prednisolone. [38]
To engage in alcohol consumption and the development of an alcohol use disorder appear to be common to primates, and is not a specific human phenomenon. [9] Humans have access to alcohol in far greater quantity than non-human primates, and the availability increased, particularly with the development of agriculture. [10]
At low or moderate doses, alcohol acts primarily as a positive allosteric modulator of GABA A. Alcohol also acts as a stimulant in low doses, as it triggers the release of dopamine in the striatum, with this mechanism also being responsible for the compound's interaction with the brain's reward system. [43]
The World Anti-Doping Agency on Monday offered an explanation for why top-ranked tennis player Jannik Sinner received a much shorter doping ban than the six-year suspension it handed to a Spanish ...
However, combinations of high doses of benzodiazepines with alcohol, barbiturates, opioids or tricyclic antidepressants are particularly dangerous, and may lead to severe complications such as coma or death. In 2013, benzodiazepines were involved in 31% of the estimated 22,767 deaths from prescription drug overdose in the United States. [5]