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That immediately gets the drug's concentration in the body up to the therapeutically-useful level. First day: 1000 mg; the body clears 100 mg, leaving 900 mg. On the second day, the patient takes 100 mg, bringing the level back to 1000 mg; the body clears 100 mg overnight, still leaving 900 mg, and so forth.
Continuing the maintenance dose for about 4 to 5 half-lives (t 1/2) of the drug will approximate the steady state level. [1] One or more doses higher than the maintenance dose can be given together at the beginning of therapy with a loading dose. [2] A loading dose is most useful for drugs that are eliminated from the body relatively slowly ...
Shamanism is a flexible custom that is embedded in a framework of cosmological beliefs and practices. [13] Shamans believe there is a spiritual connection between everything in the universe, and therefore, do not consider Shamanism to be a religion, nor a science. Instead, Shamanism can be viewed as healing or helping technology. [14]
In pharmacokinetics, the rate of infusion (or dosing rate) refers not just to the rate at which a drug is administered, but the desired rate at which a drug should be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective. Abbreviations include K in, [1] K 0, [2] or R 0.
Intraosseous infusion (IO) is the process of injecting medication, fluids, or blood products directly into the bone marrow; [1] this provides a non-collapsible entry point into the systemic venous system. [2] The intraosseous infusion technique is used to provide fluids and medication when intravenous access is not
According to Cambiaso et al, [1] slow DoS attacks exploit one or more parameters characteristics of TCP-based connections.Such parameters are exploited to keep connections alive longer than expected by preserving the attack bandwidth, hence seizing the server resources for long times, by at the same time reducing attack resources.
Context-sensitive half-life or context sensitive half-time is defined as the time taken for blood plasma concentration of a drug to decline by one half after an infusion designed to maintain a steady state (i.e. a constant plasma concentration) has been stopped. The "context" is the duration of infusion.
The shaman's song – or largish [20] in Tuvan – is personal to the shaman [21] and tells of her or his birthplace, initiation, ancestral pedigree, special gifts, and special connections to particular spirits. The melody and words are composed by the shaman and generally remain the same throughout the shaman's professional life.