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Acral peeling skin syndrome is a very rare genetic skin condition. It most commonly causes painless peeling of the top layers of skin on your hands and feet. Your arms and legs can also be...
Acral peeling skin syndrome (APSS) is an inheritable skin condition that causes painless peeling of the top layer of skin, typically on the hands or feet. This condition is very rare, and a...
Acral peeling skin syndrome is a genetic skin disorder characterized by painless peeling of the top layer of skin. Acral refers to the fact that the peeling is most apparent on the hands and feet, although peeling may also occur on the arms and legs.
Acral peeling skin syndrome (APSS) is a rare condition that affects fewer than 1000 individuals in the United States. 1 Only a few dozen cases are documented in medical literature. The hereditary skin condition is characterized by painless shedding of the epidermis. 2 The condition primarily involves extremities such as hands and feet (hence ...
"Acral" refers to the fact that the peeling of the skin is most noticeable on the hands and feet of this state. Peeling happens sometimes on the arms and legs, too. The peeling is typically apparent from birth, although it may start in childhood or later on in life as well.
Peeling skin syndrome (PSS) refers to a group of rare autosomal recessive forms of ichthyosis that is characterized clinically by superficial, asymptomatic, spontaneous peeling of the skin and histologically by a shedding of the outer layers of the epidermis.
Peeling skin syndromes (PSSs) are a heterogeneous group of rare, autosomal recessive disorders characterized by superficial, painless peeling and blistering of the skin without mucosal fragility . The two major forms are acral peeling skin syndrome (APSS; also called localized PSS) and generalized PSS [ 4-7 ].
Peeling skin syndrome belongs to the groups of congenital ichthyosis and skin fragility disorders with autosomal recessive inheritance. Most forms of PSS manifest at birth or during infancy with shedding or peeling of the outermost layer of the skin (horny layer, aka stratum corneum).
Acral PSS: Acral PSS is largely asymptomatic and the skin peeling does not lead to atrophy or scarring of that area. Patients may complain of pruritus in the denuded area. Injury, secondary infections, and scarring can arise with scratching of those areas.
The disease manifests shortly after birth or in early childhood with superficial painless peeling on the palmar, plantar and dorsal surfaces of the hands and feet, that leaves residual erythema. Superficial blisters may be seen.