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  2. Recombinant AAV mediated genome engineering - Wikipedia

    en.wikipedia.org/wiki/Recombinant_AAV_mediated...

    Recombinant adeno-associated virus (rAAV) based genome engineering is a genome editing platform centered on the use of recombinant AAV vectors that enables insertion, deletion or substitution of DNA sequences into the genomes of live mammalian cells.

  3. Self-complementary adeno-associated virus - Wikipedia

    en.wikipedia.org/wiki/Self-Complementary_Adeno...

    Self-complementary adeno-associated virus (scAAV) is a viral vector engineered from the naturally occurring adeno-associated virus (AAV) to be used as a tool for gene therapy. [1] Use of recombinant AAV (rAAV) has been successful in clinical trials addressing a variety of diseases. [ 2 ]

  4. Adeno-associated virus - Wikipedia

    en.wikipedia.org/wiki/Adeno-associated_virus

    In-vivo studies indicate that AAV vectors interact with the Toll-like receptor (TLR)9- and TLR2-MyD88 pathways to trigger the innate immune response by stimulating the production of interferons. [102] It's shown that mice deficient in TLR9 are more receptive to AAV treatment and demonstrate higher levels of transgene expression [103]

  5. She's a medical miracle. Could her animal transplant success ...

    www.aol.com/news/shes-medical-miracle-could-her...

    Why star safety Bud Clark spurned the NFL to return to TCU football for one more year. Weather. Weather. AccuWeather. Double trouble: dual winter storms to target central, eastern states next week.

  6. Gene delivery - Wikipedia

    en.wikipedia.org/wiki/Gene_delivery

    If the transgene is incorporated into somatic cells, the transgene will stay with the somatic cell line, and thus its host organism. [ 6 ] Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and also has applications in the genetic modification of crops.

  7. Vectors in gene therapy - Wikipedia

    en.wikipedia.org/wiki/Vectors_in_gene_therapy

    How vectors work to transfer genetic material. Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).

  8. Oncolytic AAV - Wikipedia

    en.wikipedia.org/wiki/Oncolytic_AAV

    It was found that AAV genome inserts in less than ~10% of occasions AAV infects a cell and the expression is less than when episomally expressed. [4] AAV can only package genomes between 2 – 5.2 kb in size when they are flanked with inverted terminal repeat sequences (ITRs), but optimally holds a genome of 4.1 to 4.9 kb in length. [ 5 ]

  9. All 67 people on board the American Airlines regional jet and US Army Black Hawk helicopter that collided midair Wednesday night are presumed dead – a grim tragedy that has left a heartbreaking ...