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  2. Markovnikov's rule - Wikipedia

    en.wikipedia.org/wiki/Markovnikov's_rule

    Such reactions are said to be anti-Markovnikov, since the halogen adds to the less substituted carbon, the opposite of a Markovnikov reaction. The anti-Markovnikov rule can be illustrated using the addition of hydrogen bromide to isobutylene in the presence of benzoyl peroxide or hydrogen peroxide. The reaction of HBr with substituted alkenes ...

  3. Hydroboration–oxidation reaction - Wikipedia

    en.wikipedia.org/wiki/Hydroboration–oxidation...

    Hydroboration–oxidation is an anti-Markovnikov reaction, with the hydroxyl group attaching to the less-substituted carbon. The reaction thus provides a more stereospecific and complementary regiochemical alternative to other hydration reactions such as acid-catalyzed addition and the oxymercuration–reduction process.

  4. Syn and anti addition - Wikipedia

    en.wikipedia.org/wiki/Syn_and_anti_addition

    If an epoxide mechanism is followed, hydroxide groups are added in an anti fashion. Neither Markovnikov or anti-Markovnikov because the substituents are the same. Hydrobromination: Stereospecific: Can be syn or anti addition, depending on situation. When alkenes undergo hydrobromination, the alkyl bromides are formed Markovnikov.

  5. Free-radical addition - Wikipedia

    en.wikipedia.org/wiki/Free-radical_addition

    [3]: 188, 751 The result is typically anti-Markovnikov addition, a phenomenon Morris Kharasch called the "peroxide effect". [4] Reaction is slower with alkynes than alkenes. [3]: 750 In the paradigmatic example, hydrogen bromide radicalyzes to monatomic bromine. These bromine atoms add to an alkene at the most accessible site, to give a ...

  6. Hydroboration - Wikipedia

    en.wikipedia.org/wiki/Hydroboration

    In terms of regiochemistry, hydroboration is typically anti-Markovnikov, i.e. the hydrogen adds to the most substituted carbon of the double bond. That the regiochemistry is reverse of a typical HX addition reflects the polarity of the B δ+-H δ− bonds. Hydroboration proceeds via a four-membered transition state: the hydrogen and the boron ...

  7. Morris S. Kharasch - Wikipedia

    en.wikipedia.org/wiki/Morris_S._Kharasch

    In 1869, a Russian chemist named Vladimir Markovnikov demonstrated that the addition of HBr to alkenes usually but not always resulted in a specific orientation. Markovnikov's rule, which stems from these observations, states that in the addition of HBr or another hydrogen halide to an alkene, the acidic proton will add to the less substituted carbon of the double bond. [3]

  8. Kharasch addition - Wikipedia

    en.wikipedia.org/wiki/Kharasch_addition

    The reaction mechanism involves free radicals of the general formula CXCl 2 (X = Cl, H). For the precursors carbon tetrachloride and chloroform, the requisite radicals can arise by abstraction of a halogen atom by a electropositive metal. The addition proceeds in an anti-Markovnikov fashion. Early work linked the addition to olefin polymerization.

  9. Thiol-ene reaction - Wikipedia

    en.wikipedia.org/wiki/Thiol-ene_reaction

    The conditions under which these cyclization reactions occur follow Baldwin's rules for ring closure. Thiosugar 5-exo and 6-endo cyclization. Intramolecular cyclization of thiyl and acyl thiyl radicals has been used to access alicyclic and heteorcyclic compounds, via anti-Markovnikov thiol-ene reactions on 1,6-dienes, under photochemical ...