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  2. Conserved signature indels - Wikipedia

    en.wikipedia.org/wiki/Conserved_signature_indels

    Conserved signature inserts and deletions (CSIs) in protein sequences provide an important category of molecular markers for understanding phylogenetic relationships. [1] [2] CSIs, brought about by rare genetic changes, provide useful phylogenetic markers that are generally of defined size and they are flanked on both sides by conserved regions to ensure their reliability.

  3. List of RNA-Seq bioinformatics tools - Wikipedia

    en.wikipedia.org/wiki/List_of_RNA-Seq...

    fastqp Simple FASTQ quality assessment using Python. Kraken: [9] A set of tools for quality control and analysis of high-throughput sequence data. HTSeq [10] The Python script htseq-qa takes a file with sequencing reads (either raw or aligned reads) and produces a PDF file with useful plots to assess the technical quality of a run.

  4. Conservative replacement - Wikipedia

    en.wikipedia.org/wiki/Conservative_replacement

    Residues that are conserved across all sequences are highlighted in grey. Below each site (i.e., position) of the protein sequence alignment is a key denoting conserved sites (*), sites with conservative replacements (:), sites with semi-conservative replacements (.), and sites with non-conservative replacements ( ).

  5. Facilitated variation - Wikipedia

    en.wikipedia.org/wiki/Facilitated_variation

    Some conserved core processes, called "exploratory processes", have the ability to generate many different phenotypical outcomes or states. Examples include: the formation of microtubule structures, the development of the nervous system (i.e. connecting of axons and target organs), synapse elimination, muscle patterning, the production of blood ...

  6. Multiple sequence alignment - Wikipedia

    en.wikipedia.org/wiki/Multiple_sequence_alignment

    A general objective function is optimized during the simulation, most generally the "sum of pairs" maximization function introduced in dynamic programming-based MSA methods. A technique for protein sequences has been implemented in the software program SAGA (Sequence Alignment by Genetic Algorithm) [ 37 ] and its equivalent in RNA is called RAGA.

  7. Sequence homology - Wikipedia

    en.wikipedia.org/wiki/Sequence_homology

    The example above is an example alloparalogy. Symparalogs are paralogs that evolved from gene duplication of paralogous genes in subsequent speciation events. From the example above, if the descendant with genes A1 and B underwent another speciation event where gene A1 duplicated, the new species would have genes B, A1a, and A1b.

  8. Sequence alignment - Wikipedia

    en.wikipedia.org/wiki/Sequence_alignment

    Another case where semi-global alignment is useful is when one sequence is short (for example a gene sequence) and the other is very long (for example a chromosome sequence). In that case, the short sequence should be globally (fully) aligned but only a local (partial) alignment is desired for the long sequence.

  9. Gene prediction - Wikipedia

    en.wikipedia.org/wiki/Gene_prediction

    Ab Initio gene prediction is an intrinsic method based on gene content and signal detection. Because of the inherent expense and difficulty in obtaining extrinsic evidence for many genes, it is also necessary to resort to ab initio gene finding, in which the genomic DNA sequence alone is systematically searched for certain tell-tale signs of protein-coding genes.