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2. Hepatotoxicity - Wikipedia

   en.wikipedia.org/wiki/Hepatotoxicity

   Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.

3. NAPQI - Wikipedia

   en.wikipedia.org/wiki/NAPQI

   NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen). [1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver.

4. Hy's law - Wikipedia

   en.wikipedia.org/wiki/Hy's_law

   Hy's law is a rule of thumb that a patient is at high risk of a fatal drug-induced liver injury if given a medication that causes hepatocellular injury (not Hepatobiliary injury) with jaundice. [1] The law is based on observations by Hy Zimmerman, a major scholar of drug-induced liver injury.

5. Paracetamol poisoning - Wikipedia

   en.wikipedia.org/wiki/Paracetamol_poisoning

   Other forms of liver support have been used including partial liver transplants. These techniques have the advantage of supporting the patient while their own liver regenerates. Once liver function returns immunosuppressive drugs are commenced and they have to take immunosuppressive medication for the rest of their lives. [86] [87]

6. Liver disease - Wikipedia

   en.wikipedia.org/wiki/Liver_disease

   Analogous terms such as "drug-induced" or "toxic" liver disease are also used to refer to disorders caused by various drugs. [ 7 ] Fatty liver disease (hepatic steatosis ) is a reversible condition where large vacuoles of triglyceride fat accumulate in liver cells. [ 8 ]

7. Download, install, or uninstall AOL Desktop Gold

   help.aol.com/articles/aol-desktop-downloading...

   Learn how to download and install or uninstall the Desktop Gold software and if your computer meets the system requirements.

8. Sagimet's shares hit new high as fatty liver disease drug ...

   www.aol.com/news/sagimets-fatty-liver-disease...

   (Reuters) -Sagimet Biosciences said on Monday its experimental drug to treat a fatty liver disease significantly reduced the symptoms in a mid-stage study, sending the drug maker's shares to an ...

9. First pass effect - Wikipedia

   en.wikipedia.org/wiki/First_pass_effect

   An example of a drug where first-pass metabolism is a complication and disadvantage is in the antiviral drug remdesivir. Remdesivir cannot be administered orally because the entire dose would be trapped in the liver with little achieving systemic circulation or reaching target organs and cells (for example, cells infected with SARS-CoV-2).