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Alanine transaminase (ALT), also known as alanine aminotransferase (ALT or ALAT), formerly serum glutamate-pyruvate transaminase (GPT) or serum glutamic-pyruvic transaminase (SGPT), is a transaminase enzyme (EC 2.6.1.2) that was first characterized in the mid-1950s by Arthur Karmen and colleagues. [1]
Combination with pyridoxine (vitamin B 6) decreases neurotoxicity but has been found to reduce the effectiveness of an altretamine/cisplatin regime. [8] MAO inhibitor can cause severe orthostatic hypotension when combined with altretamine; and cimetidine can increase its elimination half-life and toxicity.
In medicine, the presence of elevated transaminases, commonly the transaminases alanine transaminase (ALT) and aspartate transaminase (AST), may be an indicator of liver dysfunction. [ 1 ] [ 2 ] Other terms include transaminasemia , [ 3 ] and elevated liver enzymes (though they are not the only enzymes in the liver).
The proportion of AST to ALT in hepatocytes is about 2.5:1, but because AST is removed from serum by the liver sinusoidal cells twice as quickly (serum half-life t 1/2 = 18 hr) compared to ALT (t 1/2 = 36 hr), so the resulting serum levels of AST and ALT are about equal in healthy individuals, resulting in a normal AST/ALT ratio around 1.
Alagebrium (formerly known as ALT-711, dimethyl-3-N-phenacylthiazolium chloride) was a drug candidate developed by Alteon, Inc. It was the first drug candidate to be clinically tested for the purpose of breaking the crosslinks caused by advanced glycation endproducts (AGEs), thereby reversing one of the main mechanisms of aging. [ 1 ]
This is a list of software that provides an alternative graphical user interface for Microsoft Windows operating systems.The technical term for this interface is a shell. ...
The Russian National Domain Name System (Russian: НСДИ) is an alternative DNS root project started in 2019 by Roskomnadzor, a government department, [14] and is to gradually become mandatory for all ISPs in Russia. As of March 2021, servers are located on the Moscow Internet Exchange.
Alternaria alternata is a fungus causing leaf spots, rots, and blights on many plant parts, and other diseases.It is an opportunistic [citation needed] pathogen on over 380 host species of plant.