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Some people on an MDI regimen also use injection ports such as the I-port to minimize the number of daily skin punctures. The other method of intensive/flexible insulin therapy is an insulin pump. It is a small mechanical device about the size of a deck of cards. It contains a syringe-like reservoir with about three days' insulin supply.
The long acting insulin is given once (usually glargine, Lantus) or twice (usually detemir, Levemir) daily to provide a base, or basal insulin level. Rapid acting (RA) insulin is given before meals and snacks. A similar profile can be provided using an insulin pump where rapid acting insulin is given as the basal and premeal bolus insulin.
Insulin glargine sold under the brand name Lantus among others is a long-acting modified form of medical insulin, used in the management of type 1 and type 2 diabetes. [7] It is injected just under the skin . [ 7 ]
NPH insulin is cloudy and has an onset of 1–3 hours. Its peak is 6–8 hours and its duration is up to 24 hours. [9]It has an intermediate duration of action, meaning longer than that of regular and rapid-acting insulin, and shorter than long acting insulins (ultralente, glargine or detemir).
a can be mistaken as an o which could read "o.u.", meaning both eyes BDS, b.d.s. bis die sumendum: twice daily bib. bibe: drink bis bis: twice b.i.d., b.d. bis in die: twice daily AMA style avoids use of this abbreviation (spell out "twice a day") bis ind. bis indies: twice a day bis in 7 d. bis in septem diebus: twice a week BM bowel movement
A Cochrane systematic review from 2011 showed that treatment with Sulfonylureas did not improve control of glucose levels more than insulin at 3 nor 12 months of treatment. [28] This same review actually found evidence that treatment with Sulfonylureas could lead to earlier insulin dependence, with 30% of cases requiring insulin at 2 years. [28]
every month q.n. every night QNS q.n.s. quantity not sufficient q.o.d. every other day (from Latin quaque altera die) (deprecated; use "every other day" instead. See the do-not-use list) QOF: Quality and Outcomes Framework (system for payment of GPs in the UK National Health Service) q.o.h. every other hour q.s.
An important feature is the presence of zinc atoms (Zn 2+) on the axis of symmetry, which are surrounded by three water molecules and three histidine residues at position B10. [ 17 ] [ 46 ] The hexamer is an inactive form with long-term stability, which serves as a way to keep the highly reactive insulin protected, yet readily available.
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