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The oral mucosa is the mucous membrane lining the inside of the mouth. It comprises stratified squamous epithelium, termed "oral epithelium", and an underlying connective tissue termed lamina propria. [1] The oral cavity has sometimes been described as a mirror that reflects the health of the individual. [2]
Oral mucosa, however, is a complex multilayer structure with proliferating and differentiating cells and monolayer epithelial sheets have been shown to be fragile, difficult to handle and likely to contract without a supporting extracellular matrix. Monolayer epithelial sheets can be used to manufacture multilayer cultures.
Both the vestibular lamina and the dental lamina arise from a group of epithelial cells, called the primary epithelial band. [1] The vestibular lamina develops at 6th week of the intrauterine life as a result of proliferation of the primitive ectoderm that lines the primitive oral cavity. [2]
By layer, epithelium is classed as either simple epithelium, only one cell thick (unilayered), or stratified epithelium having two or more cells in thickness, or multi-layered – as stratified squamous epithelium, stratified cuboidal epithelium, and stratified columnar epithelium, [8]: 94, 97 and both types of layering can be made up of any of ...
The connective tissue of the lamina propria is loose and rich in cells. The cells of the lamina propria are variable and can include fibroblasts, lymphocytes, plasma cells, macrophages, eosinophilic leukocytes, and mast cells. [2] It provides support and nutrition to the epithelium, as well as the means to bind to the underlying tissue.
It derived from horseshoe shaped primary epithelial band which is formed when thickened oral epithelium invaginates into the mesenchyme. [4] A series of epithelial outgrowths deep into mesenchyme due to proliferation on the cranial portion of dental lamina give rise to future spot of deciduous teeth. Moreover, further proliferation on the ...
The neural tube cells give rise to the central nervous system, neural crest cells give rise to the peripheral and enteric nervous system, melanocytes, and facial cartilage, and the epidermal region will give rise to the epidermis, hair, nails, sebaceous glands, olfactory and oral epithelium, and eyes. [2]
Tooth development begins at week 6 in utero, in the oral epithelium. The process is divided into three stages: Initiation; Morphogenesis and; Histogenesis [2]; At the end of week 7 i.u., localised proliferations of cells in the dental laminae form round and oval swellings known as tooth buds, which will eventually develop into mesenchymal cells and surround the enamel organ.