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As a blood pressure medication, spironolactone is usually prescribed at a dose of 25 milligrams a day. For acne, the dosage is higher: it’s often started at 50 mg and then titrated up to 100 mg ...
High doses of oral corticosteroids ... Spironolactone is used to treat high blood pressure but is also prescribed off-label for treating acne in women. Spironolactone reduces the amount of ...
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[145] [146] [147] However, a 2017 hybrid systematic review found that the incidence of depression in women treated with spironolactone for acne was less than 1%. [64] Likewise, a 10-year observational study found that the incidence of depression in 196 transgender women taking high-dose spironolactone in combination with an estrogen was less ...
[1] [37] [126] Spironolactone is an aldosterone antagonist and is a useful acne treatment due to its ability to additionally block the androgen receptor at higher doses. [ 37 ] [ 106 ] Alone or in combination with a birth control pill, spironolactone has shown a 33 to 85% reduction in acne lesions in women. [ 117 ]
Side effects of spironolactone in clinical studies for acne in women Side effect RCTs Tooltip Randomized controlled trials (n (ITT Tooltip Intention-to-treat analysis) = 326) Case series (n (ITT Tooltip Intention-to-treat analysis) = 663) Number % Number % Menstrual irregularities: 38: 13.4 (of 283) 216: 33.4 (of 646) Breast tenderness: 8: 2.5: ...
Your acne scars will fade over time—but these creams and serums can speed things up. Dermatologists share how to find the best acne scar treatments products. ... while the 10% dose of hydroxy ...
[63] [64] [65] One study compared placebo and dosages of spironolactone of 50, 100, 150, and 200 mg/day in the treatment of acne in women and observed progressive increases in response rates up to the 200 mg/day dosage.
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