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2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [1] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
An unusual guide snoRNA U85 that functions in both 2′-O-ribose methylation and pseudouridylation of small nuclear RNA (snRNA) U5 has been identified. [14] This composite snoRNA contains both C/D and H/ACA box domains and associates with the proteins specific to each class of snoRNA (fibrillarin and Gar1p, respectively).
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U20 is encoded in intron 11 of the nucleolin gene in human, mouse and rat. [2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue U1804. [3] [4]
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from HeLa cells and expression verified by northern blotting. [2] It is predicted to guide 2'O-ribose methylation of ribosomal RNA (rRNA) 28S at residue C3866.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] [2] In humans U29 and several other snoRNAs (U22 and U25-U31) are located in the introns of the same gene (called UHG for U22 host gene). [3] [4] U29 is proposed to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA ...
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U15 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) residue A3764. [2] [3] In humans there are two closely related copies of the U15 snoRNA (called SNORD15A and SNORD15B).
U44 was originally cloned from HeLa cells and expression verified by northern blotting. [2] It is predicted to guide 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue A166. [ 3 ] In the human genome, U44 is located in the same gene as several other C/D box snoRNAs (U47, U74, U75, U76, U77, U78, U79, U80 and U81).
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] In the human genome there are two closely related copies of U58 (called U58A and U58B). They are both encoded in the introns of the ribosomal protein RPL17 gene.