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A tophus (Latin: "stone", pl.: tophi) is a deposit of monosodium urate crystals, in people with longstanding high levels of uric acid (urate) in the blood, a condition known as hyperuricemia. Tophi are pathognomonic for the disease gout. Most people with tophi have had previous attacks of acute arthritis, eventually leading to the formation of ...
If you have untreated gout for a long time, something called tophi can develop. Tophi is when uric acid crystals around the joints form larger, hard deposits. It can lead to pain, soft tissue ...
Gout presenting as slight redness in the metatarsophalangeal joint of the big toe. Gout can present in several ways, although the most common is a recurrent attack of acute inflammatory arthritis (a red, tender, hot, swollen joint). [4] The metatarsophalangeal joint at the base of the big toe is affected most often, accounting for half of cases ...
Pegloticase (trade name Krystexxa) is a medication for the treatment of severe, treatment-refractory, chronic gout. It is a third line treatment in those in whom other treatments are not effective or are not tolerated. [2] The drug is administered by infusion intravenously. Since October 2023, Amgen Inc. has been the marketer of pegloticase in ...
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One variant of is the Stainsby procedure which consists of excision of part of a proximal phalanx in a metatarsophalangeal joint, reduction of the plantar plate and kirschner wire fixation of the metacarpal bone to the remaining phalanx. [1] Resurfacing arthroplasty, where one or both bone surfaces are trimmed and replaced with a smooth metal ...
It is performed to alleviate pain, and is a salvage procedure, reserved for condition where pain can not be alleviated in any other way. It is common in veterinary surgery. Other names are excision arthroplasty of the femoral head and neck, Girdlestone's operation, Girdlestone procedure, and femoral head and neck ostectomy. [citation needed]
2073 22592 Ensembl ENSG00000134899 ENSMUSG00000026048 UniProt P28715 P35689 RefSeq (mRNA) NM_000123 NM_011729 RefSeq (protein) NP_000114 n/a Location (UCSC) Chr 13: 102.85 – 102.88 Mb Chr 1: 44.19 – 44.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA repair protein complementing XP-G cells is a protein that in humans is encoded by the ERCC5 gene. Function Excision repair ...