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About 20,000 protein coding genes are expressed in human cells and almost 75% of these genes are expressed in the normal lung. [ 83 ] [ 84 ] A little less than 200 of these genes are more specifically expressed in the lung with less than 20 genes being highly lung specific.
WI-38 was invaluable to early researchers, especially those studying virology and immunology, since it was a readily available cell line of normal human tissue. Unlike the HeLa cell line, which were cancerous cells, WI-38 was a normal human cell population. Researchers in labs across the globe have since used WI-38 in their discoveries, most ...
Type II cells are also capable of cellular division, giving rise to more type I and II alveolar cells when the lung tissue is damaged. [21] MUC1, a human gene associated with type II pneumocytes, has been identified as a marker in lung cancer. [22]
Calu-3 is a human lung cancer cell line commonly used in cancer research and drug development. Calu-3 cells are epithelial and can act as respiratory models in preclinical applications. [1] Calu-3 cells were first derived in 1975 by Germain Trempe and Jorgen Fogh of the Memorial Sloan Kettering Cancer Center.
MRC-5 (Medical Research Council cell strain 5) is a diploid cell culture line composed of fibroblasts, originally developed from the lung tissue of a 14-week-old aborted white male fetus. [ 1 ] [ 2 ] The cell line was isolated by J.P. Jacobs and colleagues in September 1966 from the seventh population doubling of the original strain, and MRC-5 ...
The lungs are the largest organs in the lower respiratory tract. The lungs are suspended within the pleural cavity of the thorax. The pleurae are two thin membranes, one cell layer thick, which surround the lungs. The inner (visceral pleura) covers the lungs and the outer (parietal pleura) lines the inner surface of the chest wall. This ...
Researchers have shown damaged lung tissue can be repaired in a small number of patients. COPD cure could come from transplanting patient’s own lung cells, say scientists Skip to main content
The end-exhalatory lung volume is now well below the resting mid-position and contains far less air than the resting "functional residual capacity". However, in a normal mammal, the lungs cannot be emptied completely. In an adult human, there is always still at least 1 liter of residual air left in the lungs after maximum exhalation. [6]