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High-dose biotin (300 mg/day = 10,000 times adequate intake) has been used in clinical trials for treatment of multiple sclerosis, a demyelinating autoimmune disease. [37] [38] The hypothesis is that biotin may promote remyelination of the myelin sheath of nerve cells, slowing or even reversing neurodegeneration. The proposed mechanisms are ...
Biotinidase deficiency is an autosomal recessive metabolic disorder in which biotin is not released from proteins in the diet during digestion or from normal protein turnover in the cell. This situation results in biotin deficiency. Biotin is an important water-soluble nutrient that aids in the metabolism of fats, carbohydrates, and proteins.
Megavitamin-B6 syndrome, also known as hypervitaminosis B6, vitamin B6 toxicity, and vitamin B6 excess, [a] is a medical condition characterized by adverse effects resulting from excessive intake of vitamin B 6. [1][2][22] Primarily affecting the nervous system, this syndrome manifests through symptoms such as peripheral sensory neuropathy ...
Reducing multiple sclerosis symptoms: Limited evidence has suggested that high-dose biotin may decrease symptoms in people with multiple sclerosis (MS). Biotin is thought to play a role in the ...
There is insufficient evidence supporting high-dose biotin [199] [200] [201] and some evidence for increased disease activity and higher risk of relapse with its use. [202] A recent review of the effectiveness of Cannabis and Cannabinoids (2022) found that compared with placebo nabiximols probably reduce the severity of spasticity in the short ...
Multiple sclerosis (MS) symptoms typically start in young adulthood, between 20 and 40 years old. However, the average age of onset depends on the type of MS. For relapsing MS, which is common in ...
Marburg acute multiple sclerosis, also known as Marburg multiple sclerosis or acute fulminant multiple sclerosis, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases. Other diseases in this group are neuromyelitis optica (NMO ...
Management of multiple sclerosis. Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS). Several therapies for it exist, although there is no known cure. The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable ...