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ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). [5][6][7] HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family.
Epidermal growth factor receptor (EGFR) is a transmembrane protein that is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGF-α). [ 7 ] ErbB2 has no known direct activating ligand, and may be in an activated state constitutively or become active upon heterodimerization with ...
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. [ 5 ][ 6 ] FGFR2 is a receptor for fibroblast growth factor. FGFR-2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly ...
Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases, ERK1,2. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Grb2 has two closely related proteins with similar domain organizations, Gads and Grap.
Key:DUYJMQONPNNFPI-UHFFFAOYSA-N. Osimertinib, sold under the brand name Tagrisso, [ 6 ] is a medication used to treat non-small-cell lung carcinomas with specific mutations. [ 7 ][ 8 ] It is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor. The most common side effects include diarrhea, rash, musculoskeletal pain ...
Fibroblast growth factor 2. Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. [5][6] It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules.
Micrograph showing hemosiderin-laden alveolar macrophages, as seen in a pulmonary hemorrhage. H&E stain.. An alveolar macrophage, pulmonary macrophage, (or dust cell) is a type of macrophage, a professional phagocyte, found in the airways and at the level of the alveoli in the lungs, but separated from their walls.
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-k Da [ 5 ] and has 53 amino acid residues and three intramolecular disulfide bonds .