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Riboswitch-controlled formation of rho-independent transcription termination hairpins leads to premature transcription termination. Riboswitch-mediated folding sequesters the ribosome-binding site, thereby inhibiting translation. The riboswitch is a ribozyme that cleaves itself in the presence of sufficient concentrations of its metabolite.
The TPP riboswitch, also known as the THI element and Thi-box riboswitch, is a highly conserved RNA secondary structure. It serves as a riboswitch [1][2] that binds thiamine pyrophosphate (TPP) directly and modulates gene expression through a variety of mechanisms in archaea, bacteria and eukaryotes. [3][4][5] TPP is the active form of thiamine ...
The NiCo riboswitch is a riboswitch that senses nickel or cobalt ions. [1] Thus, it is an RNA molecule that specifically binds these metal ions, and regulates genes accordingly. The riboswitch is thought to be a part of a system that responds to toxic levels of these metal ions, although the riboswitch might also participate in dealing with the ...
The riboswitch functions by directly sensing a physiological signal. [10] Next, a specific uncharged tRNA binds to a riboswitch element in the transcript, and a structural change occurs in the transcript that promotes expression of the downstream coding sequence. [2] [10] The specifier sequence is the first recognition sequence in the leader. [7]
Download Desktop Gold. AOL Desktop Gold is included at no additional cost with your membership. 2. Under 'All Products' scroll to 'AOL Desktop Gold'. If you have an AOL Desktop Gold trial or subscription. Using the link in the Official AOL signup confirmation email you received. 1.
A purine riboswitch is a sequence of ribonucleotides in certain messenger RNA (mRNA) that selectively binds to purine ligands via a natural aptamer domain. [1] This binding causes a conformational change in the mRNA that can affect translation by revealing an expression platform for a downstream gene, or by forming a translation-terminating stem-loop.
Glycine riboswitch. The bacterial glycine riboswitch is an RNA element that can bind the amino acid glycine. Glycine riboswitches usually consist of two metabolite-binding aptamer domains with similar structures in tandem. The aptamers were originally thought to cooperatively bind glycine to regulate the expression of downstream genes.
Free and open-source software portal Video games portal Quake Army Knife ( QuArK ) is a free and open-source program for developing 3D assets for a large variety of first-person shooters , [ 2 ] such as video games using the Quake engine by id Software or the Torque engine .