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The quantitative sudomotor axon reflex test (QSART) was developed in 1983 by Phillip Low as a quantitative method for the identification of localized postganglionic sudomotor dysfunction. [18] Three-compartment sweat capsules are placed on the forearm, proximal and distal leg, as well as the dorsum of the foot.
One clinical test for the patient that can be performed is the QSART, or the Quantitative Sudomotor Axon Reflex Testing, which stimulates the autonomic nervous system of an individual by stimulating sweat glands through the promotion of axon reflexes. [9]
This approach is primarily used in psychological studies [24] [25] rather than for assessing sudomotor function or small nerve fibers, as its poor diagnostic power in neuropathies has demonstrated. [23] [26] [27] Quantitative Sudomotor Axon Reflex Testing [28] [29]
Quantitative sudomotor axon reflex test and microneurography are used in the diagnosis of acquired idiopathic generalized anhidrosis. However, these refined methods are mostly used for research purposes and not generally available. [ 7 ]
Electrochemical skin conductance and quantitative sudomotor axon reflex testing (QSART) measures sweating response at local body sites to evaluate the small nerve fibers that innervate sweat glands. [13] Electrochemical skin conductance has been evaluated for both early diagnosis of small fiber neuropathy and follow-up of treatment efficacy.
Cold pressor test [37] Deep breathing [37] Electrochemical skin conductance [citation needed] Hyperventilation test [37] Nerve biopsy for small fiber neuropathy [1] Quantitative sudomotor axon reflex test (QSART) [37] Testing for orthostatic intolerance [37] Thermoregulatory sweat test [37] [26] Tilt table test [37] Valsalva maneuver [37] [26]
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Idiopathic pure sudomotor failure (IPSF) is the most common cause of a rare disorder known as acquired idiopathic generalized anhidrosis (AIGA), a clinical syndrome characterized by generalized decrease or absence of sweating without other autonomic and somatic nervous dysfunctions and without persistent organic cutaneous lesions.