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  2. Frameshift mutation - Wikipedia

    en.wikipedia.org/wiki/Frameshift_mutation

    A frameshift mutation can drastically change the coding capacity (genetic information) of the message. [1] Small insertions or deletions (those less than 20 base pairs) make up 24% of mutations that manifest in currently recognized genetic disease. [10] Frameshift mutations are found to be more common in repeat regions of DNA.

  3. Crick, Brenner et al. experiment - Wikipedia

    en.wikipedia.org/wiki/Crick,_Brenner_et_al...

    The Crick, Brenner et al. experiment (1961) was a scientific experiment performed by Francis Crick, Sydney Brenner, Leslie Barnett and R.J. Watts-Tobin. It was a key experiment in the development of what is now known as molecular biology and led to a publication entitled "The General Nature of the Genetic Code for Proteins" and according to the historian of Science Horace Judson is "regarded ...

  4. Slippery sequence - Wikipedia

    en.wikipedia.org/wiki/Slippery_sequence

    The frameshift occurs due to wobble pairing. The Gibbs free energy of secondary structures downstream give a hint at how often frameshift happens. [7] Tension on the mRNA molecule also plays a role. [8] A list of slippery sequences found in animal viruses is available from Huang et al. [9]

  5. Protein-truncating variants - Wikipedia

    en.wikipedia.org/wiki/Protein-truncating_variants

    This molecular biology article is a stub. You can help Wikipedia by expanding it.

  6. Mutation - Wikipedia

    en.wikipedia.org/wiki/Mutation

    Mutations that occur in coding regions of the genome are more likely to alter the protein product, and can be categorized by their effect on amino acid sequence: A frameshift mutation is caused by insertion or deletion of a number

  7. Insertion (genetics) - Wikipedia

    en.wikipedia.org/wiki/Insertion_(genetics)

    Frameshift mutations will alter all the amino acids encoded by the gene following the mutation. Usually, insertions and the subsequent frameshift mutation will cause the active translation of the gene to encounter a premature stop codon , resulting in an end to translation and the production of a truncated protein.

  8. Frame shift mutation - Wikipedia

    en.wikipedia.org/?title=Frame_shift_mutation&...

    Pages for logged out editors learn more. Contributions; Talk; Frame shift mutation

  9. Ribosomal frameshift - Wikipedia

    en.wikipedia.org/wiki/Ribosomal_frameshift

    This is a graphical representation of the HIV1 frameshift signal. A −1 frameshift in the slippery sequence region results in translation of the pol instead of the gag protein-coding region, or open reading frame (ORF). Both gag and pol proteins are required for reverse transcriptase, which is essential to HIV1 replication.