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A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin. [3] The C-type designation is from their requirement for calcium for binding. [ 4 ] Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis .
Enumeral / Merck is studying a co-blockade of PD1 and TIM3 pathways; Novartis is also testing an anti-TIM3 therapy with MBG453 (2015). CD367: Also known as CLEC4A. C-type lectin domain family 4 member A. CD368: Also known as CLEC4D. CD369: Also known as CLEC7A. C-type lectin domain family 7 member A or Dectin-1 CD370: Also known as CLEC9A. CD371
Stillmark isolated ricin, an extremely toxic hemagglutinin, from seeds of the castor plant (Ricinus communis). The first lectin to be purified on a large scale and available on a commercial basis was concanavalin A, which is now the most-used lectin for characterization and purification of sugar-containing molecules and cellular structures. [36]
In medicine these proteins are useful and are used as a mitogen to trigger T-lymphocyte cell division and to activate latent HIV-1 from human peripheral lymphocytes.In neuroscience, anterograde tracing is a research method that uses the protein product phytohaemagglutinin PHA-L as a molecular tracer that can be taken up by the cell and transported across the synapse into the next cell thereby ...
Parainfluenza hemagglutinin-neuraminidase: a type of hemagglutinin-neuraminidase produced by parainfluenza, which is closely associated with both human and veterinary disease. [17] Mumps hemagglutinin-neuraminidase: a kind of hemagglutinin that the mumps virus (MuV) produces. [18] Hemagglutinin: the PH-E form of phytohaemagglutinin.
Structure of mannose in its α-D mannopyranose form. Mannan is a polymer of mannose.. The lectin pathway or MBL pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, [1] in that, after activation, it proceeds through the action of C4 and C2 to produce activated complement proteins further down the cascade.
Hemagglutination, or haemagglutination, is a specific form of agglutination that involves red blood cells (RBCs). It has two common uses in the laboratory: blood typing and the quantification of virus dilutions in a haemagglutination assay.
In molecular biology, the galactose binding lectin domain is a protein domain. It is found in many proteins including the lectin purified from sea urchin ( Anthocidaris crassispina ) eggs, SUEL. This lectin exists as a disulfide -linked homodimer of two subunits; the dimeric form is essential for hemagglutination activity. [ 1 ]