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The drugs they studied included cocaine and a few others that have some similarities to cocaine in how they affect the brain. They trained the monkeys to give themselves these drugs through injections and observed their behavior. They wanted to see if the drugs had similar effects on the monkeys.
The neurotransmitter dopamine is a key candidate for explanation of reinforcing actions drugs. [6] [7] It's unclear to which extent NET is involved in the reinforcing actions of cocaine (an SNDRI). [8] Animal studies show evidence that inhibiting the SERT might reduce cocaine intake. [9]
Cocaine is a non-selective, competitive inhibitor of monoamine transporters, sharing a similar mechanism with that of methylphenidate. Cocaine interacts with DAT, SERT, and NET, although the behavioral and reinforcing effects of cocaine depend on its inhibition of DAT and the increase in extracellular dopamine. [1]
Locomotor activity is a measure of animal behavior which is employed in scientific research. [1] [2]Hyperlocomotion, also known as locomotor hyperactivity, hyperactivity, or increased locomotor activity, is an effect of certain drugs in animals in which locomotor activity (locomotion) is increased. [3]
Psychoactive substances often bring about subjective changes in consciousness and mood (although these may be objectively observed) that the user may find rewarding and pleasant (e.g., euphoria or a sense of relaxation) or advantageous in an objectively observable or measurable way (e.g. increased alertness), thus the effects are reinforcing to ...
San Diego sector Border Patrol agents announced the seizure of more than 80 pounds of cocaine in Temecula. The drugs were stashed inside an SUV's false dashboard, authorities said.
Cocaine (from French cocaïne, from Spanish coca, ultimately from Quechua kúka) [13] is a tropane alkaloid that acts as a central nervous system stimulant.As an extract, it is mainly used recreationally and often illegally for its euphoric and rewarding effects.
Like methadone, Suboxone blocks both the effects of heroin withdrawal and an addict’s craving and, if used properly, does it without causing intoxication. Unlike methadone, it can be prescribed by a certified family physician and taken at home, meaning a recovering addict can lead a normal life, without a daily early-morning commute to a clinic.