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Isosorbide dinitrate is available as a generic medication. [1] [5] A long-acting form exists. [1] In 2022, isosorbide was the 119th most commonly prescribed medication in the United States, with more than 5 million prescriptions. [6] [7]
A nitrovasodilator is a pharmaceutical agent that causes vasodilation (widening of blood vessels) by donation of nitric oxide (NO), [1] and is mostly used for the treatment and prevention of angina pectoris. This group of drugs includes nitrates (esters of nitric acid), which are reduced to NO in the body, as well as some other substances.
The nitrate esters isosorbide dinitrate (Isordil) and isosorbide mononitrate (Imdur, Ismo, Monoket, Mononitron) are converted in the body to nitric oxide, a potent natural vasodilator. In medicine , these esters are used as a medicine for angina pectoris ( ischemic heart disease ).
Isosorbide mononitrate, sold under many brand names, is a medication used for heart-related chest pain , heart failure and esophageal spasms. [2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers . [ 2 ]
In the medical field, nitrate-derived organic esters, such as glyceryl trinitrate, isosorbide dinitrate, and isosorbide mononitrate, are used in the prophylaxis and management of acute coronary syndrome, myocardial infarction, acute pulmonary oedema. [10] This class of drug, to which amyl nitrite also belongs, is known as nitrovasodilators.
By nitration of isosorbide with concentrated nitric acid, 2,5-isosorbide dinitrate (ISDN) can be obtained. 2,5-isosorbide dinitrate is suitable (just like its major metabolite 5-isosorbide mononitrate, ISMN [6]) for the treatment of angina pectoris due to its vasodilator effect. [7]
February 5, 2025 at 2:03 AM. Whether you’re in the midst of a HIIT class or training for a marathon, our bodies run on adrenaline to lock in and finish a challenging workout.
Molsidomine is a prodrug that is hydrolysed to linsidomine (SIN-1) in the liver via first-pass effect, which subsequently releases NO. 44–59% of molsidomine reach the bloodstream in unchanged form, 3–11% of which are bound to plasma proteins.
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related to: isosorbide dinitrate mononitrate equivalent to 10 5 1- 109 S High St #100, Columbus, OH · Directions · (614) 224-4261
