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ATtRACt database: a database of RNA binding proteins and associated motifs. SplicedAid-F: a database of hand -cureted human RNA binding proteins database. RsiteDB: RNA binding site database; SPOT-Seq-RNA: Template-based prediction of RNA binding proteins and their complex structures. SPOT-Struct-RNA: RNA binding proteins prediction from 3D ...
StarBase also developed Pan-Cancer Analysis Platform to decipher Pan-Cancer Analysis Networks of lncRNAs, miRNAs, ceRNAs, and RNA-binding proteins (RBPs) by mining clinical and expression profiles of 14 cancer types (including more than six thousand samples) from The Cancer Genome Atlas (TCGA) Data Portal.
Heterogeneous nuclear ribonucleoprotein H is a protein [5] that in humans is encoded by the HNRNPH1 gene. [6] [7] This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins . The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA .
Recent discoveries implicating RNA in the pathogenesis of several forms of cancer and neuromuscular diseases have created a paradigm shift in drug discovery.This work combined with advances in structural characterization techniques such as NMR spectroscopy, X-ray crystallography, Cryogenic electron microscopy [1] together with computational modeling, [2] has pushed forward the realization that ...
The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [ 7 ]
20218 Ensembl ENSG00000121774 ENSMUSG00000028790 UniProt Q07666 Q60749 RefSeq (mRNA) NM_001271878 NM_006559 NM_011317 RefSeq (protein) NP_001258807 NP_006550 NP_035447 Location (UCSC) Chr 1: 32.01 – 32.06 Mb Chr 4: 129.6 – 129.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans ...
The perinucleolar compartment was first discovered due to characterizing the polypyrimidine tract-binding protein (PTB), which is an RNA binding protein involved with pre-mRNA splicing, stability, and regulating translation. [7] The PTB and other binding proteins are localized in the PNC to primarily process RNA polymerase II.
The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRNPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [6]