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Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease, is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral) as well as inhibiting mRNA export.
RNase H is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism, aided by an enzyme-bound divalent metal ion. RNase H leaves a 5'-phosphorylated product. [7] EC 3.1.26.3: RNase III is a type of ribonuclease that cleaves rRNA (16s rRNA and 23s rRNA) from transcribed polycistronic RNA operon in prokaryotes. It ...
RNase MRP: mitochondrial RNA processing ribonuclease RF00030: RNase P: ribonuclease P RF00010: A type of ribonuclease which cleaves RNA scaRNA: small Cajal body-specific RNA RF00553: scnRNA small-scan RNA - scRNA small cytoplasmic RNA - scRNA: small conditional RNA - SgrS RNA: sugar transport-related sRNA RF00534
246730 Ensembl ENSG00000089127 ENSMUSG00000052776 UniProt P00973 P11928 RefSeq (mRNA) NM_001032409 NM_002534 NM_016816 NM_001320151 NM_145211 RefSeq (protein) NP_001027581 NP_001307080 NP_002525 NP_058132 NP_660212 Location (UCSC) Chr 12: 112.91 – 112.93 Mb Chr 5: 121.03 – 121.05 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 2'-5'-oligoadenylate synthetase 1 is an enzyme that ...
Three sequences, UAG, UGA, and UAA, known as stop codons, [note 1] do not code for an amino acid but instead signal the release of the nascent polypeptide from the ribosome. [7] In the standard code, the sequence AUG—read as methionine—can serve as a start codon and, along with sequences such as an initiation factor, initiates translation.
6059 24015 Ensembl ENSG00000164163 ENSMUSG00000058355 UniProt P61221 P61222 RefSeq (mRNA) NM_002940 NM_001040876 NM_015751 RefSeq (protein) NP_001035809 NP_002931 NP_056566 Location (UCSC) Chr 4: 145.1 – 145.13 Mb Chr 8: 80.41 – 80.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ATP-binding cassette sub-family E member 1 (ABCE1) also known as RNase L inhibitor (RLI) is an ...
This poly(A) tail promotes degradation by the degradosome, which contains two RNA-degrading enzymes: polynucleotide phosphorylase and RNase E. Polynucleotide phosphorylase binds to the 3′ end of RNAs and the 3′ extension provided by the poly(A) tail allows it to bind to the RNAs whose secondary structure would otherwise block the 3′ end.
Another cellular enzyme, RNAse L—also induced by interferon action—destroys RNA within the cells to further reduce protein synthesis of both viral and host genes. Inhibited protein synthesis impairs both virus replication and infected host cells.